Geisinger IHC: Stains are a good thing. Quality stains are OUR thing! IHCFAQ.COM
New Antibodies

Geisinger IHC continually tests new antibodies, new clones, new panels and protocols to determine the best possible marker or panel of markers to use in our practice. The latest antibodies we've added to our test menu are:

Loss of DAXX in metastatic pancreatic NET.

Expression of ATRX/DAXX is seen in stromal cells, endothelial cells and inflammatory cells as an internal positive control. DAXX is reported to be lost in approximately 50 percent of metastatic pancreatic NETs

Loss of ATRX in metastatic pancreatic NET.

Expression of ATRX/DAXX is seen in stromal cells, endothelial cells and inflammatory cells as an internal positive control. ATRX is reported to be lost in approximately 50 percent of metastatic pancreatic NETs

Nuclear staining of a leiomyosarcoma.

Loss of H3K27me3expression has been reported in 50% of malignant peripheral nerve sheath tumors.

Nuclear staining of a yolk sac tumor.

Nuclear staining of a yolk sac tumor. PLZF has been reported to be negative in other germ cell tumors.

NKX3.1 in metastatic prostatic adenocarcinoma

NK3 homeobox 1 (NKX3.1) is a highly sensitive and specific nuclear staining marker for both primary and metastatic prostatic adenocarcinomas (ADCs) and has been reported in virtually 100% of prostatic ADCs.

NKX2.2 in Ewing sarcoma/PNET

NKX2.2 is a transcription factor with a crucial role in differentiation of the central nervous system and pancreatic islets, which has been demonstrated to be expressed in 93% of Ewing sarcomas/PNETs. Shown to be a more sensitive and specific marker than CD99 and friend leukemia virus integration 1 (Fli-1) for Ewing sarcoma/PNET based on the limited literature.

Cadherin-17 in colon medullary carcinoma

New marker for intestinal differentiation. Usually positive in CDX2-, CK20-colorectal cancer.

ADFP (adipophilin) in sebaceous carcinoma

A potential marker to discriminate sebaceous carcinoma from BCC or SCC. Also positive in xanthomatous lesions and renal cell carcinoma metastatic to skin.

SATB2 4X

A highly sensitive and specific marker for colorectal carcinomas and osteosarcoma. It is usually negative in upper GI and pancreatobiliary carcinomas and carcinomas from other organs. Rare small intestinal adenocarcinoma could express SATB-2.

SATB2 in colon medullary carcinoma

New marker for intestinal differentiation. Usually positive in CDX2-, CK20- colorectal cancer. Potential marker to discriminate small intestinal from colorectal cancer. Also a specific marker for osteoblastic differentiation.

TROP2 staining in papillary thyroid carcinoma

A new diagnostic marker for papillary thyroid carcinomas (PTC), positive in 90% of cases; usually negative in thyroid follicular adenoma or carcinoma. Also positive in 100% of low-grade non-invasive papillary urothelial carcinomas.

SOX11 in mantle cell lymphoma

SOX11 is specifically is expressed in the nucleus of Mantle cell lymphomas (MCL) compared with other lymphomas and benign lymphoid tissue and is a useful immunohistochemical marker for both cyclin D1-positive and negative MCL.

TFF1 staining in breast carcinoma

Usually positive in breast carcinomas and colon adenocarcinomas, and negative in lung adenocarcinomas, endometrial adenocarcinomas and ovarian serous carcinomas.

ERG in prostatic adenocarcinoma

A highly sensitive and specific marker for benign and malignant vascular tumors; it also expresses in 50% of prostatic carcinomas.

GATA3 in urothelial carcinoma

A highly sensitive and specific marker for breast and urothelial primaries when working on a tumor of unknown origin. Approximately 70% of ER-negative breast carcinomas are also positive for GATA3.

Antibody List

Click here for a complete list of the stains we perform.

Order Form

IHC Order FormWhen sending your specimen to an IHC lab, you need fast, accurate and reliable results each and every time. Geisinger IHC maintains a level of excellence in our methodologies, testing controls, and reporting that goes beyond industry standards. When you work with Geisinger IHC, you can be sure that your test results are accurate, thorough and validated.

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