Anticoagulation Impact on Coagulation Tests

Pathology & Laboratory Medicine- May 1, 2020
Reviewed by Michelle Grant, DO 5/1/2020

 

Class of Drug Drugs of Each Class
Unfractionated heparin (UFH) Heparin
Low Molecular Weight Heparin (LMWH) & Fondaparinux Enoxaparin (Lovenox), Dalteparin (Fragmin)
Vitamin K antagonists Warfarin (Coumadin, Jantoven)
Direct thrombin inhibitor (DTI) Dabigatran (Pradaxa), Argatroban, Hirudin, Bivalirudin
Xa Inhibitors Rivaroxaban (Xarelto), Apixaban (Eliquis), Edoxaban (Savaysa & Lixiana)

 

 

 

 

 



Anticoagulant

PT

aPTT

UFH

Fib

DD

ACT

PT & aPTT Mixing Study

AT3

TT

Rep

DRVV

LaPTT

PC Act

PS Act

PST

PSF

vWF Ant

F2

F7

F8

F9

F10

Vitamin K Antagonist ↑ ↑ 0-↑ 0 0 0 0-↑ Correction into normal range 0 0-↑ 0 ↑↑ ↑↑ 0 0 0 ↓↓ ↓↓ 0 ↓↓ ↓↓
UFH, standard IV or high SC 0-↑ ↑↑ 0 0 ↑↑ Incomplete correction (inhibitor) 0 ↑↑ 0 ↑↑ ↑↑ 0 0 0 0 0
LMWH & Fondaparinux 0 0-↑ 0 0 0-↑ Incomplete correction (inhibitor) 0 0-↑ 0 0-↑ 0-↑ 0 0 0 0 0
DTI* 0-↑ ↑↑ 0 0-↓ 0 ↑↑ Incomplete correction (inhibitor) ↑↑ 0 ↑↑ 0 0 0 0 ↓↓ ↓↓ ↓↓ 0-↓
Xa Inhibitor* ↑↑ 0-↑ ↑↑ 0 0 ↑↑ Incomplete correction (inhibitor) 0 0 0 ↑↑ 0-↑ 0 0 0 0 0 0 0 0

↑ = prolonged clotting time or increased activity, ↓ = shortened clotting time or decreased activity, 0 = no change

ACT- activated clotting time, DD- D-dimer, Fib- fibrinogen, DRVV- dilute Russel Viper Venom Time, F- factor, LAPTT- Lupus Sensitive aPTT, PC act- Protein C activity, PS act- Protein S activity, PSF- Protein S free, PST- Protein S total, Rep- reptilase, TT- thrombin time, UFH- unfractionated heparin (anti-Xa chromogenic assay), vWF Ant- von Willebrand factor antigen.

*DOAC quantitative measurements (drug concentration) are not available at Geisinger Medical Laboratories and are a send out test only.

Please contact Laboratory Client Services (1-800-695-6491) with any questions.

























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