Youzhong Yuan, MD, PhD

Dr.  Youzhong YuanYouzhong Yuan, MD, PhD
Anatomic Pathology, Clinical Pathology, Hematopathology

1000 East Mountain Boulevard
Wilkes-Barre, PA 18711
1 800 695 6491

Dr. Yuan is an Associate of Geisinger Medical Laboratories at Geisinger Wyoming Valley (GWv) Medical Center in Wilkes-Barre, Pennsylvania..


He received his M.D. from Second Military Medical University and his PhD from Fudan University, both in Shanghai, China. Dr. Yuan completed pathology residency training at Conemaugh Memorial Medical Center in Johnstown, Pennsylvania, where he was chief resident, and at the University of California, San Diego. He also completed a hematopathology fellowship at Yale-New Haven Hospital in New Haven, Connecticut.


Dr. Yuan is board certified in anatomic and clinical pathology and hematopathology.

Professional Affiliations:

College of American Pathologists
American Society for Clinical Pathology
Society of Hematopathology

Recent Academic Activity

Publications in Peer-Reviewed Journals:

Urbaniak A, Piña-Oviedo S, Yuan Y, Huczynski A, Chambers TC. Limitations of an ex vivo breast cancer model for studying the mechanism of action of the anticancer drug paclitaxel. Eur J Pharmacol. 2021 891:173780.

LoBianco FV, Krager KJ, Carter GS, Alam S, Yuan Y, Lavoie EG, Dranoff JA, Aykin-Burns N. The Role of Sirtuin 3 in Radiation-Induced Long-Term Persistent Liver Injury. Antioxidants (Basel). 2020 May 11;9(5):409.

Urbaniak A, Jousheghany F, Piña-Oviedo S, Yuan Y, Majcher-Uchanska U, Klejborowska G, Moorjani A, Monzavi-Karbassi B, Huczynski A, Chambers TC. Carbamate derivatives of colchicine show potent activity towards primary acute lymphoblastic leukemia and primary breast cancer cells-in vitro and ex vivo study. J Biochem Mol Toxicol. 2020 Mar 5:e22487.

Xiu Y, Dong Q, Fu L, Bossler A, Tang X, Boyce B, Borcherding N, Leidinger M, Sardina JL, Xue HH, Li Q, Feldman A, Aifantis I, Boccalatte F, Wang L, Jin M, Khoury J, Wang W, Hu S, Yuan Y, Wang E, Yuan J, Janz S, Colgan J, Habelhah H, Waldschmidt T, Müschen M, Bagg A, Darbro B, Zhao C. Coactivation of NF-?B and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion. Blood. 2020; 135(2):108-120.

Post GR, Yuan Y, Holthoff ER, Quick CM, and Post S. Identification of a Novel Monocytic Phenotype in Classic Hodgkin Lymphoma Tumor Microenvironment. PLoS One. 2019; 14(11):e0224621.

Urbaniak A, Jousheghany F, Yuan Y, Piña-Oviedo S, Huczynski A, Delgado M, Kieber-Emmons T, Monzavi-Karbassi B, Chambers TC. The response of phyllodes tumor of the breast to anticancer therapy: An in vitro and ex vivo study. Oncol Lett. 2019 Nov;18(5):5097-5106.

Madan E, Pelham CJ, Nagane M, Parker TM, Canas-Marques R, Fazio K, Shaik K, Yuan Y, Henriques V, Galzerano A, Yamashita T, Pinto MAF, Palma AM, Camacho D, Vieira A, Soldini D, Nakshatri H, Post SR, Rhiner C, Yamashita H, Accardi D, Hansen LA, Carvalho C, Beltran AL, Kuppusamy P, Gogna R, Moreno E. Flower isoforms promote competitive growth in cancer. Nature. 2019; 572:260-264.

Haque L, Villanueva M, Russo A, Yuan Y, Lee EJ, Topal J, Podoltsev N. A rare case of visceral leishmaniasis in an immunocompetent traveler returning to the United States from Europe. PLoS Negl Trop Dis 2018; 12(10):e0006727.

Antoszczak M, Urbaniak A, Delgado M, Maj E, Borgström B, Wietrzyk J, Huczynski A, Yuan Y, Chambers TC, Strand D. Biological activity of doubly modified salinomycin analogs - Evaluation in vitro and ex vivo. Eur J Med Chem. 2018;156:510-523.

Blossom SJ, Fernandes L, Bai S, Khare S, Gokulan K, Yuan Y, Dewall M, Simmen F, Gilbert K. Opposing Actions of Developmental Trichloroethylene and High-Fat Diet Coexposure on Markers of Lipogenesis and Inflammation in Autoimmune-Prone Mice. Toxicol Sci. 2018; 164:313-327.

Gralewski JH, Post GR; van Rhee F and Yuan Y. Myeloid transformation of plasma cell myeloma: Molecular evidence of clonal evolution revealed by next generation sequencing. Diagn Pathol 2018 Feb 20;13(1):15.

Pan Z, Chen M, Zhang Q, Wang E, Yin L, Xu Y, Huang Q, Yuan Y, Zhang X, Zheng G, Yuan J. CD3-positive plasmablastic B-cell neoplasms : A diagnostic pitfall. Mod Path 2018 ; 31(5):718-731.

Post GR, Bell RC, Rjoop A, Lobo RH, Yuan Y, Post SR. Diagnostic Utility of Interleukin-6 Expression by Immunohistochemistry in Differentiating Castleman Disease Subtypes and Reactive Lymphadenopathies. Ann Clin Lab Sci 2016 Sep; 46(5):474-9.

Gao Y, Yang P, Shen H, Yu H, Song X, Zhang L, Zhang P, Cheng H, Xie Z, Hao S, Dong F, Ma S, Ji Q, Bartlow P, Ding Y, Wang L, Liu H, Li Y, Cheng H, Miao W, Yuan W, Yuan Y, Cheng T, Xie XQ. Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of hematopoietic stem cells. Nat Commun. 2015;6:6328.

Abstracts, Posters, and Other Presentations:

University of Arkansas for Medical Sciences, Cancer Institute Grand Rounds; “Hodgkin Lymphoma: The Past, the Present and the Future”. Little Rock, AR, August 23, 2017.

Gralewski J, Post GR, Yuan Y. Myeloid Sarcoma with Monocytic Differentiation and IGH-MAF Gene Rearrangement. Society of Hematopathology Workshop 2017, Chicago

Connecticut Society for Hematopathology Annual Meeting; “Diffuse Large B-cell Lymphoma in CNS”. New Haven, CT. February, 2015.

University of Arkansas for Medical Sciences; Dept. of Pathology; “Primary Breast Lymphoma: Pitfalls in Diagnosis”; April, 2015.

University of Arkansas for Medical Sciences, Cancer Institute Grand Rounds; “Primary Breast Lymphoma”. Little Rock, AR, August 12, 2015.


Locations  |    Search  |    Site Map |   Contact Us

©2000-2022 Geisinger Health System.   All rights reserved.