Dr. Fan Lin
FAN LIN, MD PhD
Anatomic and Clinicl Pathology, Cytopathology
Vice Chair, Anatomic Pathology
100 North Academy Avenue
Danville, PA 17822-1920
800-695-6491
Dr. Lin is the vice chair of Laboratory Medicine and division chief of Anatomic Pathology Professional Services and Development. He is also on the faculty of the Geisinger Cytopathology Fellowship Program and Pathology Residency Program.
Education:
Dr. Lin obtained his M.D. from Fujian Medical University, Fuzhou, in the People's Republic of China. He completed his residency in anatomic pathology at the University of Chicago Hospital in Illinois, and a fellowship in cytopathology at the University of Texas, M.D. Anderson Cancer Center in Houston.
Certifications:
He is board certified in anatomic, clinical and cytopathology Dr. Lin's areas of specialization are cervical gynecologic, gastrointestinal, genitourinary, renal, thyroid, and urologic pathology, and cytopathology.
Professional Affiliations:
College of American Pathologists
United States and Canadian Academy of Pathology
American Society of Cytopathology
PA Pathology Society
Research Interests:
Immunohistochemistry, Cytopathology.
Recent Academic Activity
Publications in Peer-Reviewed Journals:
Lynn TJ, Shi J, Liu H, Monaco S, Prichard JW, Lin F. Trichorhinophalangeal Syndrome Type 1 Is a Highly Sensitive and Specific Marker for Diagnosing Triple-Negative Breast Carcinomas on Cytologic Samples. Arch Pathol lab Medi. 2023; https://doi.org/10.5858/arpa.2022-0411-OA: .
Sarami I, Shi J, Lin B, Liu H, Monroe R, Lin F. Evaluation of Human Kidney Injury Molecule-1 (hKIM-1) Expression in Tumors from Various Organs by mRNA in situ Hybridization. Am J Clin Pathol. 2021; February:Epub ahead of print .
Li Y, Liu F, Zhou W, Zhang S, Chu P, Lin F, Wang HL. Diagnostic value of clusterin immunostaining in hepatocellular carcinoma. Diagn Pathol. 2021; 15(1):127 .
Diehl DL, Mok SRS, Khara HS, Johal AS, Kirchner HL, Lin F . Heparin priming of EUS-FNA needles does not adversely affect tissue cytology or immunohistochemical staining. Endosc Int Open. 2018; 6(3):E356-E362 .
Liu H, Ljungren C, Lin F, Zarka MA, and Chen L. Analysis of Histologic Follow-up and Risk of Malignancy for Salivary Gland Neoplasm of Uncertain Malignant Potential Proposed by the Milan System for Reporting Salivary Gland Cytopathology. Cancer Cytopathol. 2018; 126(7):490-497 .
Yin W, Zhang PL, Macknis JK, Lin F, Bonventre JV. Kidney injury molecule-1 identifies antemortem injury in postmortem adult and fetal kidney. Am J Physiol Renal Physiol. 2018; 315(6):F1637-F1643 .
Liu H, Shi J, Lin F. The potential diagnostic utility of TROP-2 in thyroid neoplasms. Appl Immunohistochem Mol Morphol. 2017; 25(8):525-533 .
Lin F, Shi J, Ma X, et al. Detection of albumin expression by RNA in situ hybridization in hepatocellular carcinomas and intrahepatic cholangiocarcinomas. Am J Clin Pathol. 2017; In :preparation .
Liu H, Shi J, Ma X, Lin F, et al. RNA in situ hybridization is a more sensitive method than immunohistochemistry in detection of GCDFP15 in breast carcinomas. Am J Clin Pathol. 2017; In :preparation .
Wang HL, Kim CJ, Koo J, Zhou W, Choi EK, Arcega R, Chen ZE, Wang H, Zhang L, Lin F. Practical immunohistochemistry in neoplastic pathology of the gastrointestinal tract, liver, biliary tract, and pancreas. Arch Pathol Lab Med. 2017; 141:155-1180 .
Kandukuri SR, Lin F, Gui L, Gong Y, Fan F, Chen L, Cai G, Liu H. Application of Immunohistochemistry in Undifferentiated Neoplasms: A Practical Approach. Arch Pathol Lab Med. 2017; 141(8):1014-1032 .
Zhang L, Lin FH. Best Practices in Immunohistochemistry in Surgical Pathology and Cytopathology. Arch Pathol Lab Med. 2017; 141(8):1011-1013 .
Other Publications:
Chen Z, Liu J, Lin F. Q&A Column: How can one wisely apply GATA3 immunohistochemistry as a useful tumor marker in diagnostic surgical pathology?. CAP Today October 2018, 1, 2018.
Abstracts, Posters, and Other Presentations:
Lynn TJ, Frank R, Pramick MR, Lin F, Monaco SE. Rotation of ROSEs: Workload and Reimbursement Analysis of System-wide Telecytology ROSE coverage in a Multi-site Rural Health System. Platform Presentation. American Society of Cytopathology Annual Meeting, Baltimore, Maryland, October 2022.
Joseph N, Snyder D, Lin F, Frank R, Monaco SE. Impact of Telecytology Implementation on utilization and diagnostic categories in different cytopathology specimen sources. Poster Presentation. American Society of Cytopathology, Chicago, IIllinois, November 17-20, 2021.
Tang X, Shi J, Lin F, Monroe R and Liu H. MYB Expression by RNA In-Situ Hybridization is Sensitive and Specific for Adenoid Cystic Carcinoma. Abstract and virtual poster. United States and Canadian Academy of Pathology, Virtual meeting, March 2021.
Tang X, Shi J, Lin F and Liu H. Nuclear Expression of NR4A3 by Immunohistochemistry Distinguishes Acinic Cell Carcinoma from its Mimics on Fine-Needle Aspiration Samples. Abstract and virtual platform presentation. United States and Canadian Academy of Pathology, Virtual meeting, March 2021.
Wall S, Liu H, Lin F, Shi J. Evaluation of VSTM2a Expression in Various Renal and Urothelial Tumors by mRNA In Situ Hybridization. Abstract and virtual poster. United States and Canadian Academy of Pathology, Virtual meeting, March 2021.
Wall S, Shi J, Bitting A, Lin F. Immunohistochemical Evaluation of SMARCA4 and SMARCA2 Expression in Tumors from Various Organs. Poster. United States and Canadian Academy of Pathology, Baltimore, Maryland, March 13-18, 2021.
Rizwan R, SHi J, Bitting A, Liu H, Lin F. Immunohistochemical Evaluation of SS18-SSX and SSX Expression in Synovial Sarcomas and Mimickers with Previous FISH Analysis for SS18 Rearrangement. Poster. United States and Canadian Academy of Pathology, Baltimore, Maryland, March 13-18, 2021.
Tabish N, Absar F, Shi J, Bitting A, Liu H, Lin F. Immunohistochemical Evaluation of Mannose Binding Lectin Antibody (EPR18381) on Tumors from Various Organs. Poster. United States and Canadian Academy of Pathology, Baltimore, Maryland, March 13-18, 2021.
Albert J, Berger A, Liu H, Lin F. Risk Stratification of Papillary Thyroid Microcarcinoma, A Retrospective Cohort Study. Oral Presentation. American Association of Clinical Endocrinologists 29th Annual Scientific & Clinical Congress, Washington, DC, May 6-10, 2020.
Mohammad M, Shi J, Liu H, Lin F. Immunohistochemical evaluation of insulinoma-associated protein 1 (INSM1) expression on tumors and normal tissues from various organs. Abstract. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020.
Absar F, Shi J, Liu H, Lin F. Immunohistochemical evaluation of loss of expression of BRCA-1 associated protein 1 (BAP1) on tumors and normal tissues from various organs. Abstract. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020.
Zelonis M, Shi J, Liu H, Monroe R, Lin F. Detection of cervical squamous dysplasia on cell blocks prepared from Pap test samples - A combined study based on morphology, HPV detection by RNA in situ hybridization, and immunohistochemical stains for p16 and Ki-67. Abstract. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020.
Tabish N, SHi J, Liu H, Lin F. Immunohistochemical evaluation of nuclear protein in testis (NUT) expression on tumors and normal tissues from various organs. . Abstract. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020.
Mohammad M, Shi J, Li A, Liu H, Lin F. Immunohistochemical evaluation of orthopedia homeobox (OTP) expression on tumors and normal tissues from various organs. Abstract. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020.
Kim P, Lin F, Shi J, Bitting A, Liu H. Use of Immunohistochemistry to Distinguish Normal Gastric and Duodenal Mucosa from Intraductal Papillary Mucinous Neoplasms. Abstract. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020.
Melanie R, Shi J, Lin F, Kim P, Liu H. INSL3 is a Specific Biomarker for Leydig Cells, Leydig Cell Hyperplasia and Leydig Cell Tumors. Poster. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020..
Melanie R, Lin F, Zelonis M, Liu H. Analysis of Cytology Pap Tests with High-Risk HPV Cotesting and a Three-Year Follow-Up on NILM/HPV+ Group in a Tertiary Care Setting. Poster. United States and Canadian Academy of Pathology , Los Angeles, California, February 29-March 5, 2020..
Zhang B, Lin F, Frank R, Liu, H. The Reduction of Atypia of Undetermined Significance (AUS)/Follicular Lesion of Undetermined Significance (FLUS) Rate by Quality Assurance Measures and Their Financial Impact. Presentation. 25th Annual Geisinger Scholarship Days, Danville, Pennsylvania, April 2019.
Lin F, SHi J, Chen , Yin H, Monroe R, Liu H. Detection of Anaplastic Lymphoma Kinase (ALK) Gene Rearrangement by RNA in situ Hybridization in Lung Adenocarcinomas. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Zhang B, Lin F, Frank R, Liu H. The reduction of atypia of undetermined significance (AUS)/follicular lesion of undetermined significance (FLUS) rate by quality assurance measures and their financial impact. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Sarami I, Shi J, Lin B, Liu H, Monroe R, Lin F. Evaluation of Human Kidney Injury Molecule-1 (hKIM-1) Expression in Tumors from Various Organs by mRNA in situ Hybridization. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Lin B, Zelonis M, Lin F, Liu H. Accuracy between ThyroSeq v2 and ThyroSeq v3 Molecular Test for Indeterminate Thyroid Nodules. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Liu H, Shi J, Monroe R, Lin F. Utility of T RO P-2 by RNA in situ Hybridization in Diagnosing Papillary Thyroid Carcinomas. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Lockhart V, Lin F, et al. A Comparison of Whipple Grossing Methods: Whole Mount Versus Conventional. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Lockhart V, Lin F, et al. Whole Mount Grossing of Whipple Specimens: Histology Techniques and Outcomes. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Chen Z, Sarami I, Quinones w, Lin F. Whole Mount Grossing of Whipple Specimens: Histology Techniques and Outcomes. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, National Harbor, Maryland, March 16-21, 2019.
Shi J, Lin B, Monroe R, Lin F. Detection of BK Polyomavirus in Allograft Renal Biopsies – Comparison of Diagnostic Sensitivity and Specificity of RNA in situ Hybridization vs. Immunohistochemistry. Presentation. College of American Pathologists, Orlando, Floria, October 20-24-2018.
Liu H, Bitting A, Lin D, Lin F. Immunohistochemical Detection of PD-L1 Expression on Bladder Small Cell Carcinomas Using Ventana SP263 Clone. Presentation. College of American Pathologists, Orlando, Floria, October 20-24-2018.
Lin F, Shi J, Lin B, Li A, Liu H. Immunohistochemical Detection of EGFR L858R Mutation in Lung Adenocarcinomas Using a Point Mutation Specific Monoclonal Antibody. Presentation. College of American Pathologists, Orland, Floria, October 20-24-2018.
Rosengrant AJ, Lin F, Liu H. The Analysis and Diagnostic Correlation of NIFTP with Previous Thyroid Fine Needle Aspiration Specimens. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, Vancouver, British Columbia, March 17-23, 2018.
Borodin VS, Lin F, Liu H. Immunohistochemical Evaluation of PAX-8 Expression in Various Benign Fluid Specimens. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, Vancouver, British Columbia, March 17-23, 2018.
Liu H, Shi J, Lin D, Li A, Lin F. Immunohistochemical Evaluation of PAX-6 in Neuroendocrine and Non-neuroendocrine Tumors from Various Organs. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, Vancouver, British Columbia, March 17-23, 2018.
Lin F, Shi J, Bitting A, Lin B, Liu H. Impact of Decalcification Time on Immunohistochemical Detection of PD-L1 Expression in Cultured Carcinoma Cell Lines. Presentation. United States and Canadian Academy of Pathology (USCAP) Meeting, Vancouver, British Columbia, March 17-23, 2018.
Liu H, Shi J, Lin F. . Immunohistochemical detection of VHL expression is more sensitive than detection of albumin mRNA in the diagnosis of intrahepatic cholangiocarcinomas on fine needle aspiration and small tissue biopsy specimens. Presentation. American Society of Cytopathology, Phoenix, Arizona, November 10-17, 2017.
Lin F, Bitting A, Liu H. Immunohistochemical profiles of normal testicular adnexal structures – rete testis, epididymis and vas deferens. Presentation. College of American Pathologists, Oxon Hill, Maryland, October 8-11, 2107.
Lin F, Bitting A, Chen Z, Liu H. Immunohistochemical Evaluation and Comparison of Expression of Three Thyroid Transcription Factor 1 (TTF1) Clones in Neoplasms and Normal Tissues. Presentation. College of American Pathologists, Oxon Hill, Maryland, October 8-11, 2107.
Liu H, SHi J, Lin F. The Validation and Utility of Immunoassay for CK 8/18 on Frozen Tissue Section. Presentation. College of American Pathologists, Oxon Hill, Maryland, October 8-11, 2107.
Lin F. The Third CAPA-China Pathology meeting. Organizer. CAPA, San Antonio, Texas, March 4, 2017.
Lin F, et al. Detection of albumin expression by RNA in situ hybridization is a sensitive and specific method for identification of hepatocellular carcinomas and intrahepatic cholangiocarcinomas. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Piazza Y, Liu H, Lin F. Immunohistochemical Detection of Loss Expression of ATRX/DAXX in Neuroendocrine Tumors from Various Organs. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Swarrow RS, Liu H, Lin F. Diagnostic Utility of VHL, Maspin, IMP3 and S100P in the Evaluation of Pancreatic Resection Margins from Frozen Tissue. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Piazza Y, Lin F, Liu H. The Correlation of Afirma® Gene Expression Classifier Results with Follow-Up Findings for Thyroid Fine Needle Aspiration Specimens. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Swarrow RS, Lin F, Liu H. Analysis of the atypia of undetermined significance/follicular lesion of undetermined significant (AUS/FLUS) category – experience from a large health system. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Chen ZE, Bitting A, Lin F. Assessment of PD-L1 expression in tumor microenvironment of mismatch repair deficient colon cancer: comparing two antibody clones, SP142 vs. SP263. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Zhang S, Liu F, Shi J, Chi P, Lin F, Stellino A, Shen H, Wang HL. Diagnostic Value of Clusterin Immunostaining in Hepatocellular Carcinoma: A Comparison with pCEA and CD10. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Liu H, Wilkerson M, Lin F. NKX3.1 is the Most Sensitive Immunohistochemical Marker in Identifying Metastatic Prostatic Carcinomas. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Liu H, Wilkerson M, Lin F. Immunohistochemical Evaluation of NKX3.1 Expression in Prostatic Ductal Adenocarcinomas. Poster presentation. United States and Canadian Academy of Pathology, San Antonio, Texas, March 4-10, 2017.
Textbook Chapters
Chen G, Chen E, Li J, Li J, and Lin F. Lower gastrointestinal tract and microsatellite instability (MSI). In Handbook of Practical Immunohistochemistry-Frequently Asked Questions, 3rd ed. Lin F, Prichad J, Liu H, WIlkerson M, eds. Springer, New York, New York, 2022, 701-714.
Wilkerson M, Hewitt S. Tissue Microarray. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 3rd ed. Lin F, Prichard J, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 161-172.
Liu H, Wilkerson M, Lin F. Thyroid, parathyroid and adrenal glands. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 3rd ed. Lin F, Prichard J, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 339-374.
Wilkerson M, Cheng L. Urinary bladder and urachus. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 3rd ed. Lin F, Prichard J, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 551-574.
Wilkerson M, Cheng L. Testis and paratesticular tissues. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 3rd ed. Lin F, Prichard J, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 607-628.
Chen Z, Ding Y, Lin F. Overview of Immunohistochemistry Assessment of Cancer-Related Predictive Biomarkers and Common Genetic Alterations. In Handbook of Practical Immunohistochemistry-Frequently Asked Questions, 3rd ed. Lin F, Prichard J, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 131-160.
Zhang M, Ding Y. Lymph node. In Handbook of Practical Immunohistochemistry-Frequently Asked Questions, 3rd ed. Lin F, Prichard J, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 751-798.
Yin H, Ding Y, Quinones W, Zelonis M, Snyder D. Application of Fluorescent In Situ Hybridization (FISH) in Surgical and Cytologic Specimens (Solid Tumors, Hematopoietic Tumors, Urine, Bile Duct Brushing, and Bronchoscopy). In Handbook of Practical Immunohistochemistry-Frequently Asked Questions, 3rd ed. Lin F, Prichard J, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 975-1006.
Kazmi S, Wu H, Schuerch C. Central Nerve System. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 3rd ed. Lin F, Prichard JW, Liu H, Wilkerson M, eds. Springer, New York, New York, 2022, 313-338.
Ferringer T. Skin. In Handbook of Practical Immunhistochemistry-Frequently Asked Questions, 3rd ed. Lin F, Prichard JW, Wilkerson M, Chen ZM, eds. Springer, New York, NY, 2022, 921-954.
Frank R, Meschter SC. Exfoliative Cytology and Effusions. In Handbook of Practical Immunohistochemistry: Frequently Asked Questions, 3rd ed. Lin F, Prichard JW, Liu H, Wilkerson M, eds. Springer, New York, NY, 2022, 233-252.
Lin F, Liu H, Zhang J. . In Handbook of Practical Fine Needle Aspiration and Small Tissue Biopsies. Lin F, Liu H, Zhang J, eds. Springer, New York, NY, 2017, *.