Zachary S. Hoffer, MD, PhD

Anatomic and Clinical Pathology, Neuropathology
Director of the Pathology Residency Program.

100 North Academy Avenue
Danville, PA 17822-1920

Dr. Hoffer is Geisinger Medical Laboratories' system director for Surgical Pathology and  Histology. His areas of specialization include neuropathology, breast, cervical and gynecologic pathology, GI, thoracic, and genitourinary pathology. He is also the director of the Pathology Residency Program.


Dr. Hoffer received his MD from Drexel University College of Medicine, Philadelphia, Pennsylvania, and his PhD in neuroscience and neuroanatomy from Pennsylvania State University College of Medicine, Milton Hershey Medical Center, Hershey, Pennsylvania. He completed his pathology residency at Madigan Army Medical Center, Fort Lewis, Washington, and a fellowship in neuropathology at University of Washington, Harborview Medical Center, Seattle, Washington. Dr. Hoffer was also trained in and practiced pathology in the U.S. Army Medical Corps for 12 years.


Dr. Hoffer is board-certified in anatomic and clinical pathology and neuropathology.

Professional Affiliations

College of American Pathologists

Research Interests

Dr. Hoffer’s research interests include neuropathologic and neurodegenerative diseases and traumatic brain injury.

Recent Academic Activity

Publications in Peer-Reviewed Journals:

Kuckelman JP, Kononchik J, Smith J, Kniery KR, Kay JT, Zachary S. Hoffer, Steele SR, Sohn V.Human-Derived Amniotic Membrane Is Associated With Decreased Postoperative Intraperitoneal Adhesions in a Rat Model. Dis Colon Rectum. 2018 Apr;61(4):484-490

Latimer CS, Flanagan ME, Cimino PJ, Jayadev S, Davis M, Zachary S. Hoffer, Montine TJ, Gonzalez-Cuyar LF, Bird TD, Keene CD. Neuropathological Comparison of Adult Onset and Juvenile Huntington's Disease with Cerebellar Atrophy: A Report of a Father and Son. J Huntingtons Dis. 2017 Oct 11. doi: 10.3233/JHD-170261. [Epub ahead of print].

Black GE, Sokol KK, Shawhan R, Eckert MJ, Salgar S, Marko ST, Zachary S. Hoffer, Martin MJ.  Inducing metabolic suppression in severe hemorrhagic shock: pilot study results from the biochronicity project. J Trauma Acute Care Surg. 2016 Dec;81(6):1003-1011.

Huber BR, Meabon JS, Zachary S. Hoffer, Zhang J, Hoekstra JG, Pagulayan KF, McMillan PJ, Mayer CL, Banks WA, Kraemer BC, Raskind MA, McGavern DB, Peskind ER, Cook DG. (2016) Blast exposure causes dynamic microglial/macrophage responses and microdomains of brain microvessel dysfunction. Neuroscience. Jan 14. pii: S0306-4522(16)00041-5.

Nelson DW, Black GE, Thomas RL, Eckert MJ, Zachary S. Hoffer, Martin MJ. (2015).  Sugar or salt? The relative roles of the glucocorticoid and mineralocorticoid axes in traumatic shock. J Trauma Acute Care Surg. Dec;79(6):1023-9.

Satterly SA, Salgar S, Zachary S. Hoffer, Hempel J, DeHart MJ, Wingerd M, Raywin H, Stallings JD, Martin M. (2015) Hydrogen sulfide improves resuscitation via non-hibernatory mechanisms in a porcine shock model. J Surg Res. Apr 9 epub ahead of print.

Hoekstra JG, Cook TJ, Stewart T, Mattison H, Dreisbach MT, Zachary S. Hoffer, Zhang J. (2015) Astrocytic Dynamin-Like Protein 1 Regulates Neuronal Protection against Excitotoxicity in Parkinson Disease. Am J Pathol. Feb;185(2):536-49.

Jones MD, Sweet KJ, Zachary S. Hoffer. (2015) Retained viable plant material in the calcaneus a case report of a 22-year-old soldier with atypical heel pain. J Am Podiatr Med Assoc. Jan;105(1):92-5.

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