Geisinger Medical Laboratories Test Catalog
FIBRINOGEN |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2283 Geisinger Epic ID: 7170 | |
SPECIMEN COLLECTION |
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Specimen type: |
Platelet-poor plasma | |
Preferred collection container: |
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Alternate Collection Container: |
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
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Specimen required: |
1 mL | |
Special notes: |
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SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge specimen immediately at designated time and speed to obtain platelet-poor plasma (<10,000/µL). Using a plastic pipette, carefully remove plasma from cells, avoiding platelet/buffy layer by leaving a thin layer of plasma on top the cells. The centrifuged plasma should be aliquoted (1 mL per aliquot) into clearly labeled polypropylene tubes. The number of tests ordered will determine the aliquots needed. Check the residual specimen for clot and if present discard sample and redraw specimen. If plasma is icteric, lipemic or hemolyzed a lab comment should be generated to notify staff. Freeze upright in non-thaw freezer. | |
Transport temperature: |
Plasma (on or off packed cells): Room temperature Plasma off cells: Frozen on dry ice |
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Specimen stability: |
Room temperature (plasma on cells): 4 hours Room temperature (plasma off cells): 8 hours Frozen (plasma) -20°C: 2 weeks Frozen (plasma) -70°C: 6 months |
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Rejection criteria: |
Clotted, hemolyzed, improperly filled tubes, improper anticoagulant ratio (HCT >55% and citrate not adjusted), refrigerated specimens, or stability exceeded.
Note: Specimen suspected of thawing in transport, indicated by slant in aliquot or specimen in lid of tube, will have testing performed, and the comment “interpret results with caution as thawing suspected” added to results. |
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TEST DETAILS |
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Reference interval: |
178-467 mg/dL | |
Critical values/courtesy alerts: |
<60 mg/dL | |
Additional information: |
Anticoagulation Impact on Coagulation Tests | |
CPT code(s): |
85384 | |
Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Fibrinogen activity. | |
Methodology: |
Clauss Thrombin Clotting Rate Assay |
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Synonyms: |
Factor I
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Clinical significance: |
A soluble plasma protein that is converted by thrombin to form an insoluble fibrin clot. It also plays a role in platelet activation and aggregation.
Hypofibrinogenemia, or low fibrinogen levels, may be congenital or acquired from bleeding, disseminated intravascular coagulopathy (DIC) or severe liver disease. Levels may be elevated in chronic inflammation, pregnancy, or early/moderate liver disease. Dysfibrinogenemia, or an abnormal fibrinogen protein, may result in bleeding or thrombosis. Dysfibrinogenemia may result in low levels using this methodology, therefore, if suspected recommend comparing results to a fibrinogen antigen level. In patients with dysfibrinogenemia the fibrinogen activity and fibrinogen antigen levels will be different. |
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Doctoral Director(s:) |
Michelle Grant DO | |
Review Date: | 03/28/2023 |
Performing Locations
Geisinger Wyoming Valley Medical Center
Geisinger Community Medical Center