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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
IGG SYNTHESIS RATE/INDEX, CSF |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB3730 Geisinger Epic ID: 145808 | |
SPECIMEN COLLECTION |
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Specimen type: |
CSF AND serum | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
1 mL (minimum 0.5 mL) aliquot of serum AND 2 mL (minimum 1 mL) CSF | |
Special notes: |
BOTH serum AND CSF required. The collection date and time is preferred to be the same for both specimens (maximum 48-hour duration between CSF and serum draw times). Both CSF and serum must be sent for calculation of synthesis rate by nephelometry. CSF must be crystalline clear. Light, moderate, or grossly hemolyzed CSF samples will not be accepted. Serum separator tubes also acceptable | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Refrigerate CSF specimens. Centrifuge and transfer serum specimens to clean, plastic, screw-capped vial(s). | |
Transport temperature: |
Transport both specimens refrigerated (cold packs) in the same shipping container. | |
Specimen stability: |
Room Temperature: 8 hours. Refrigerated: 1 week. Frozen: 3 months. | |
Rejection criteria: |
Received room temperature. Hemolysis. Xanthochromia/RBCs/hemolysis in CSF. | |
TEST DETAILS |
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Additional information: |
The IgG Synthesis Rate, CSF, and IgG Index, CSF, are two formulae for estimating the amount of IgG produced in the central nervous system. | |
CPT code(s): |
82042, 82040, 82784 x2 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
IGG synthesis rate. | |
Methodology: |
Nephelometry |
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Synonyms: |
IGG SYNTHESIS RATE Quest test code 7558 CSFIGS
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Clinical significance: |
Evidence of increased synthesis of IgG in CSF provides support for the diagnosis of multiple sclerosis. | |