Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

IGG SYNTHESIS RATE/INDEX, CSF

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB3730         Geisinger Epic ID: 145808

SPECIMEN COLLECTION
Specimen type:
CSF AND serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
1 mL (minimum 0.5 mL) aliquot of serum AND 2 mL (minimum 1 mL) CSF
Special notes:
BOTH serum AND CSF required. The collection date and time is preferred to be the same for both specimens (maximum 48-hour duration between CSF and serum draw times). Both CSF and serum must be sent for calculation of synthesis rate by nephelometry. CSF must be crystalline clear. Light, moderate, or grossly hemolyzed CSF samples will not be accepted. Serum separator tubes also acceptable

SPECIMEN PROCESSING
Specimen processing instructions:
Refrigerate CSF specimens. Centrifuge and transfer serum specimens to clean, plastic, screw-capped vial(s). 
Transport temperature:
Transport both specimens refrigerated (cold packs) in the same shipping container.
Specimen stability:
Room Temperature: 8 hours. Refrigerated: 1 week. Frozen: 3 months.
Rejection criteria:
Received room temperature. Hemolysis. Xanthochromia/RBCs/hemolysis in CSF.

TEST DETAILS
Reference interval:
IgG Synthesis Rate, CSF-9.9 - +3.3 mg/day
IgG Index, CSF< 0.66
Albumin, CSF 8.0 - 42.0 mg/dL
IgG, CSF 0.8 - 7.7 mg/dL
IgG, Serum: See report.
Albumin, Serum: See report.
Additional information:
The IgG Synthesis Rate, CSF, and IgG Index, CSF, are two formulae for estimating the amount of IgG produced in the central nervous system.
CPT code(s):
82042, 82040, 82784 x2
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
IGG synthesis rate.
Methodology:
Nephelometry
Synonyms:
IGG SYNTHESIS RATE
Quest test code 7558
CSFIGS
Clinical significance:
Evidence of increased synthesis of IgG in CSF provides support for the diagnosis of multiple sclerosis.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Mon-Sat; Report available: Next day.    
Performed stat? No
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