Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

BNP (NT-PROBNP)

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1873         Geisinger Epic ID: 21325

SPECIMEN COLLECTION
Specimen type:
Plasma or serum
Preferred collection container:
Specimen required:
2 mL aliquot serum or plasma; minimum 0.5 mL.
Special notes:
PLASMA FROM EDTA LAVENDER-TOP TUBES CANNOT BE USED.
Patient preparation:
If patient is receiving biotin, no sample is to be taken until at least 8 hours after last biotin administration.

SPECIMEN PROCESSING
Specimen processing instructions:
Allow serum to clot. Centrifuge to separate serum or plasma. 
Transport temperature:
Room temperature (preferred).
Specimen stability:
Room temperature: 3 days. Refrigerated: 6 days. Frozen: 24 months.
Rejection criteria:
Stability limits exceeded.

TEST DETAILS
Interpretation guide:
Adults:
Exclude Heart Failure: <300 pg/mL
Diagnose Heart Failure:
Age <50 yr: >450 pg/mL
50-75 yr: >900 pg/mL
>75 yr: >1800 pg/mL
*GFR is 30-59 mL/min: > 1200 pg/mL or age-adjusted values
GFR < 30 mL/min: do not use, not reliable
Prognostic threshold: 1000 pg/mL

Children:
NT-ProBNP (as well as BNP) values are generally very high at birth and rapidly fall within the first few weeks. Pediatric reference intervals below are based on Nir et al Pediatr Cardiol (2009, 30:3-8) and other studies.
0-2 days: 321-13222 pg/mL
3-11 days: 263 -6502 pg/mL
>1 mo to 1 year: 37-1000 pg/mL
>1 to 2 years: 39-675 pg/mL
>2 to 6 years: 23-327 pg/mL
CPT code(s):
83880
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Methodology:
Electrochemiluminescence Immunoassay
Synonyms:
proBNP
PRO BNP; BNPNTPRO; BNP-NTPRO; NTPROBNP; NT-PROBNP
PRO BRAIN NATRIURETIC PEPTIDE
Clinical significance:
N terminal pro B-type natriuretic peptide (NTproBNP) is a split product of proBNP that correlates with release of this hormone during left vetricular dysfunction and heart failure. NTproBNP does not suffer interference from exogenous BNP used to treat congestive heart failure.
Doctoral Director(s:)
Hoi-Ying Elsie Yu, PhD, DABCC
Sheng-Ying (Margaret) Lo, PhD, DABCC    
Review Date: 11/16/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Automated Chemistry
Technical Lead: Mariana Moyer, Jared Shepherd
Frequency: Daily, Monday-Sunday
Performed stat? Yes

Geisinger Wyoming Valley Medical Center

Performing laboratory: ATL+
Technical Lead: Sarah McGowan    
Frequency: Daily, all shifts    
Performed stat? Yes

Geisinger Shamokin Area Community Hospital

Performing laboratory: Chemistry
Technical Lead: Anthony Cole    
Frequency: Daily, all shifts    
Performed stat? Yes

Geisinger Bloomsburg Hospital

Performing laboratory: Chemistry
Technical Lead: Robyn Stokes  
Frequency: Daily    
Performed stat? Yes

Geisinger Community Medical Center

Performing laboratory: Chemistry
Technical Lead: Ann Mack, Deborah Dempsey  
Frequency: Daily, all shifts    
Performed stat? Yes

Geisinger Lewistown Hospital

Performing laboratory: Chemistry
Technical Lead: Melissa Forsythe  
Frequency: Daily, all shifts    
Performed stat? Yes

Geisinger Jersey Shore Hospital

Performing laboratory: Chemistry
Technical lead: Brenda Shuman-Johnson    
Frequency: Daily, all shifts    
Performed stat? Yes

Geisinger South Wilkes-Barre

Technical lead: Bernadette Johnson    
Frequency: Daily, all shifts    
Performed stat? Yes
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