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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
ACETYLCHOLINE RECEPTOR BINDING ANTIBODY |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1508 Geisinger Epic ID: 6981 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
3.5 mL gold-top (serum separator) tube
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Specimen required: |
1 mL aliquot of serum; minimum 0.5 mL. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Allow to clot. Centrifuge 10 minutes at 3000 rpm. | |
Transport temperature: |
Room temperature (preferred). Refrigerated or frozen specimen also acceptable. | |
Specimen stability: |
Room Temperature: 14 days. Refrigerated: 14 days. Frozen: 30 days. | |
Rejection criteria: |
Microbially contaminated. Gross hemolysis. Grossly lipemic. | |
TEST DETAILS |
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Interpretation guide: |
Negative =0.30 nmol/L Equivocal 0.31-0.49 nmol/L Positive =0.50 nmol/L |
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CPT code(s): |
83519 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Acetylcholine Receptor Binding Antibody. | |
Methodology: |
Radioimmunoassay (RIA) |
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Synonyms: |
AChR Binding Antibodies, Quest test code 206, ACETYL
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Clinical significance: |
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. This assay aids in the differential diagnosis of conditions with MG-like muscle weakness and in monitoring therapeutic response. If binding antibodies are negative, assays for modulating and blocking antibodies should be considered. | |