Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

IGF BINDING PROTEIN-3 (IGFBP-3)

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB2516         Geisinger Epic ID: 17696

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
1 mL aliquot of serum; minimum 0.5 mL.

SPECIMEN PROCESSING
Specimen processing instructions:
Allow to clot. Centrifuge 10 minutes at 3000 rpm. 
Transport temperature:
Room temperature.
Specimen stability:
Room Temperature: 7 days. Refrigerated: 14 days. Frozen: 1 year (-20°C).
Rejection criteria:
Gross hemolysis • Grossly lipemic

TEST DETAILS
CPT code(s):
83520
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
IgF binding protein 3
Methodology:
Immunoassay
Synonyms:
IGF, Binding Protein 3, IGFB3
Quest test code 34458
Clinical significance:
Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the six distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II. IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in cromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Thus, both assays and the ratios of IGF-I/IGFBP-2 and IGFBP-2/IGFBP-3 are useful as markers of GH action and for discriminating between growth hormone deficiency and short stature due to other etiologies in children. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Tuesday-Saturday. Report available: Same day.    
Performed stat? No
Locations  |    Search  |    Site Map |   Contact Us
©2000-2021 Geisinger Health System.   All rights reserved.