Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

IGFBP3

ORDERING INFORMATION:
Sunquest Test Code:
IGFB3      Geisinger Epic Procedure Code: 83519.03         Geisinger Epic ID: 17696

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
3.5 mL gold-top (serum separator) tube
Specimen required:
1 mL aliquot of serum; minimum 0.5 mL. Please submit a separate frozen aliquot for this test. It may not be combined with any other test requiring a frozen aliquot.

SPECIMEN PROCESSING
Specimen processing instructions:
Allow to clot. Centrifuge 10 minutes at 3000 rpm. 
Transport temperature:
Refrigerated or frozen.
Specimen stability:
Room Temperature: 7 hours. Refrigerated: 14 days. Frozen: 1 year (-20°C).
Rejection criteria:
Samples received at room temperature are not acceptable.

TEST DETAILS
Reference interval:
IGFBP-3:
1-7 days<0.7 mg/L
8-15 days 0.5-1.4 mg/L
16 da-1 yr 0.7-3.6 mg/L
2 years 0.8-3.9 mg/L
3 years 0.9-4.3 mg/L
4 years 1.0-4.7 mg/L
5 years 1.1-5.2 mg/L
6 years 1.3-5.6 mg/L
7 years 1.4-6.1 mg/L
8 years 1.6-6.5 mg/L
9 years 1.8-7.1 mg/L
10 years 2.1-7.7 mg/L
11 years 2.4-8.4 mg/L
12 years 2.7-8.9 mg/L
13 years 3.1-9.5 mg/L
14 years 3.3-10.0 mg/L
15 years 3.5-10.0 mg/L
16 years 3.4-9.5 mg/L
17 years 3.2-8.7 mg/L
18 years 3.1-7.9 mg/L
19 years 2.9-7.3 mg/L
20 years 2.9-7.2 mg/L
21-30 years3.4-7.8 mg/L
31-40 years3.4-7.0 mg/L
41-50 years3.3-6.7 mg/L
51-60 years3.4-6.9 mg/L
61-70 years3.0-6.6 mg/L
71-80 years2.5-5.7 mg/L
81-85 years2.2-4.5 mg/L
>85 years No primary data available; use 81-85 year range as a guideline.

By pubertal (Tanner) stage, Females
Tanner I 1.2-6.4 mg/L
Tanner II 2.8-6.9 mg/L
Tanner III 3.9-9.4 mg/L
Tanner IV 3.3-8.1 mg/L
Tanner V 2.7-9.1 mg/L

By pubertal (Tanner) stage, Males
Tanner I1.4-5.2 mg/L
Tanner II 2.3-6.3 mg/L
Tanner III 3.1-8.9 mg/L
Tanner IV 3.7-8.7 mg/L
Tanner V 2.6-8.6 mg/L
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
IgF binding protein 3
Methodology:
Immunoassay
Synonyms:
IGF, Binding Protein 3
Quest test code 34458
Clinical significance:
Insulin-like growth factor binding proteins bind IGF-I and IGF-II with high affinity but do not bind insulin. Of the six distinct IGF binding proteins structurally characterized at this time, IGFBP-3 has been shown to be the major carrier of the IGFs, transporting approximately 95% of circulating IGF-I and IGF-II. IGFBP-3 is growth hormone (GH) responsive. Thus, levels are high in cromegaly and low in hypopituitarism, and levels increase in GH-deficient children after GH administration. Thus, both assays and the ratios of IGF-I/IGFBP-2 and IGFBP-2/IGFBP-3 are useful as markers of GH action and for discriminating between growth hormone deficiency and short stature due to other etiologies in children. Other causes of short stature that result in reduced IGFBP-3 levels include poorly controlled diabetes. The IGFBP-3 assay is useful in assessing nutritional status, since IGFBP-3 decreases during both caloric and protein restriction.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Monday-Friday evening    
Performed stat? No
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