Geisinger Medical Laboratories Test Catalog
SOLUBLE FIBRIN MONOMERS |
||
ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB3072 Geisinger Epic ID: 7159 | |
SPECIMEN COLLECTION |
||
Specimen type: |
Platelet-poor plasma | |
Preferred collection container: |
||
Alternate Collection Container: |
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
|
|
Specimen required: |
1 mL | |
Special notes: |
|
|
SPECIMEN PROCESSING |
||
Specimen processing instructions: |
Immediately transport at room temperature to Coagulation Laboratory after collection. Centrifuge within 60 minutes at designated speed and time to obtain platelet-poor plasma (<10,000/µL). Using a plastic pipette, carefully remove plasma from cells, avoiding platelet/buffy layer by leaving a thin layer of plasma on top the cells. The centrifuged plasma should be aliquoted (1 mL per aliquot) into clearly labeled polypropylene tubes. | |
Transport temperature: |
Room temperature | |
Specimen stability: |
Room temperature: 2 hours | |
Rejection criteria: |
Clotted, hemolyzed, improperly filled tubes, improper anticoagulant ratio (HCT >55% and citrate not adjusted), refrigerated or frozen specimens, or stability exceeded. | |
TEST DETAILS |
||
Reference interval: |
Negative | |
CPT code(s): |
85366 | |
Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Qualitative hemagglutination |
|
Synonyms: |
Fibrin Monomer, Soluble Fibrin Monomers, SFM
|
|
Clinical significance: |
The assay can assist in diagnosing disseminated intravascular coagulation (DIC). Fibrin monomers are produced as soluble fibrinogen is transformed into insoluble fibrin clot. This intermediate product can form soluble complexes with fibrinogen or fibrinogen degradation products when thrombin levels are low (commonly observed in patients with DIC). These soluble complexes are then visualized using RBC agglutination. DIC is a clinical diagnosis, and no single test should be used to diagnose DIC. This assay should be correlated with other DIC tests (PT, APTT, D-Dimer, and platelet count). In neonates, interpret samples with caution, as the results are often positive, due to difficulty in sample collection. | |
Doctoral Director(s:) |
Michelle Grant DO | |
Review Date: | 03/30/2023 |