Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
SOLUBLE FIBRIN MONOMERS |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB3072 Geisinger Epic ID: 7159 | |
SPECIMEN COLLECTION |
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Specimen type: |
Platelet-free plasma | |
Preferred collection container: |
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Alternate Collection Container: |
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
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Specimen required: |
1 mL aliquot of plasma; minimum 1 mL. | |
Special notes: |
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SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge within 60 minutes at designated speed and time to obtain platelet-poor plasma (<10,000/µL) and submit platelet free plasma. | |
Transport temperature: |
Room temperature. DO NOT FREEZE. | |
Specimen stability: |
Stable for 2 hours at 15-25ºC. | |
Rejection criteria: |
Clotted specimen or underfilled or overfilled tube. Stability limits exceeded. HCT > 55%. | |
TEST DETAILS |
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Reference interval: |
Negative. | |
CPT code(s): |
85366 | |
Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Qualitative hemagglutination |
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Synonyms: |
Fibrin Monomer, Soluble Fibrin Monomers, SFM
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Clinical significance: |
The assay can assist in diagnosing disseminated intravascular coagulation (DIC). Fibrin monomers are produced as soluble fibrinogen is transformed into insoluble fibrin clot. This intermediate product can form soluble complexes with fibrinogen or fibrinogen degradation products when thrombin levels are low (commonly observed in patients with DIC). These soluble complexes are then visualized using RBC agglutination. DIC is a clinical diagnosis, and no single test should be used to diagnose DIC. This assay should be correlated with other DIC tests (PT, APTT, D-Dimer, and platelet count). In neonates, interpret samples with caution, as the results are often positive, due to difficulty in sample collection. | |
Doctoral Director(s:) |
Michelle Grant DO | |
Review Date: | 02/09/2023 |