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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
CRYOGLOBULIN REFLEX PROFILE |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2102 Geisinger Epic ID: 27337 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Specimen required: |
Two (2) 1-2 mL aliquots in plain red-top (non-serum separator) tubes. | |
Special notes: |
Two (2) 6 mL plain red-top (nonserum separator) tubes are required. Refer to special Specimen Processing Instructions (below) before collecting specimen for this test. | |
Patient preparation: |
Fasting specimen preferred. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Incubate tubes at 37°C (water bath/dry incubator) for 60 minutes before centrifuging. Centrifuge and take off serum into two (2) plain red-top (nonserum separator) tubes. Label tubes as serum. Alternate Processing Procedure if waterbath/dry incubator not available: Sandwich specimens between two phlebotomy heat packs (activate them first). Place heat packs with specimens into a styrofoam container and incubate 60 minutes (for specimen to clot). Centrifuge and take off serum into two (2) plain red-top (nonserum separator) tubes. Label take off tubes as serum. If special processing requirements are unable to be met, please refer patient to GMC Danville, GWV, GBH or GSACH campus for collection. |
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Transport temperature: |
Room temperature. | |
Specimen stability: |
Sample must be received by the Receiving and Processing Department (RAP) in Danville within 24 hours of processing. See specimen processing instructions | |
Rejection criteria: |
Improper processing. | |
TEST DETAILS |
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Reference interval: |
None detected. | |
Additional information: |
Test progresses to a % cryocrit and immunofixation (IFES) at an additional charge if a cryoglobulin is detected. | |
CPT code(s): |
82595 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Qualitative screening for a cryoprecipitate. If a cryoprecipitate is detected a % cryocrit and immunofixation are performed. | |
Methodology: |
Precipitation Immunofixation Turbidimetric |
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Synonyms: |
CRYOSC
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Clinical significance: |
Cryoglobulins are immunoglobulins that precipitate out of solution below core body temperatures. In some instances, cryoglobulinemia may coexist with other related but usually distinct forms of cold hypersensitivity such as Raynaud's phenomenon or cold agglutinin activity. | |
Doctoral Director(s:) |
Hoi-Ying Elsie Yu PhD, DABCC | |
| Review Date: | 12/13/2022 | |