Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB2493         Geisinger Epic ID: 19453

Specimen type:
Preferred collection container:
Alternate Collection Container:
Lavender-top (K2 EDTA) microcollection tube
Specimen required:
1 mL aliquot of plasma; minimum 0.5 mL.
Special notes:
If collecting specimen in microcollection tubes, collect 3 FULL lavender microcollection tubes
Patient preparation:
Fasting is not required, but homocysteine can increase 10 to 15% after a high-protein meal.

Specimen processing instructions:
Place the specimen in a refrigerator or ice bath until the specimen can be centrifuged. Centrifuge the specimen as soon as possible and separate plasma from cells immediately after centrifugation. Aliquot. 
Transport temperature:
Refrigerated. Frozen if stability may be exceeded.
Specimen stability:
After separation, stable 14 days at 2-8°C or 6 months at -20°C. Note: Due to the special handling requirements of this test. it cannot be added on to other lavender-top (EDTA) tubes.
Rejection criteria:
Specimen will be rejected if stability limit is exceeded or if specimen is hemolyzed, lipemic, or icteric.

Reference interval:
5-15 µmol/L.
Additional information:
WARNING: Patients taking S-adenosyl-methionine may show falsely elevated levels of homocysteine. Patients taking methotrexate, nicotinic acid, theophylline, nitrous oxide, or L-dopa can have falsely elevated homocystine levels.
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Homocysteine value.
Chemiluminescence Immunoassay
Clinical significance:
This diagnostic test is designed to quantitatively measure HCY in EDTA plasma. Such measurement can aid in the diagnosis and treatment of patients suspected of having homocysteinemia or hyperhomocysteinemia.
Doctoral Director(s:)
Hoi-Ying Elsie Yu, PhD, DABCC
Stacy Kenyon, PhD, DABCC
Review Date: 12/02/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Karen Delp
Frequency: Five days a week, 1st shift.
Performed stat? No
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