Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

NEURON SPECIFIC ENOLASE

ORDERING INFORMATION:
Sunquest Test Code:
NSE      Geisinger Epic Procedure Code: 86316.05         Geisinger Epic ID: 43083

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
3.5 mL gold-top (serum separator) tube
Specimen required:
1 mL aliquot of serum; minimum 0.2 mL.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge and immediately separate serum specimens from the cells into clean, plastic, screw-capped vial(s). 
Transport temperature:
Room temperature, refrigerated (preferred) or frozen.
Specimen stability:
Room temperature: 7 days. Refrigerated (cold packs): 14 days (preferred). Frozen: 30 days.
Rejection criteria:
NSE is high in platelets and in RBCs; therefore, plasma and hemolyzed specimens are unacceptable. Obtain hemolysis-free serum.

TEST DETAILS
Reference interval:
NSE, Adults: Less than 10.8 ng/mL
CPT code(s):
86316
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Neuron-specific enolase.
Methodology:
Immunoassay
Synonyms:
NSE
Quest test code 34476
Clinical significance:
Elevated levels of serum NSE are reported in patients with small cell carcinomas primarily of lung origin. Patients with neuroblastomas may also have high levels of NSE. Serum NSE can be used to monitor recurrence or progression of tumor in these cancer patients. Daily serial monitoring of serum NSE may also be used in comatose patients to assess neuronal damage. High NSE levels in comatose patients at 24hr and 48hr post cardio-pulmonary resusitation have been associated with poor outcome. Hemolysis can cause false positive results.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Tuesday, Friday morning    
Performed stat? No
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