Geisinger Medical Laboratories Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB2236             Geisinger Epic ID: 6615

Specimen type:
Serum (preferred) or plasma.
Preferred collection container:
Alternate Collection Container:
3 mL green/yellow-top (plasma separator) tube
Specimen required:
1 mL of serum (preferred) or plasma; minimum 0.5 mL

Specimen processing instructions:
Allow serum to clot. Centrifuge to separate serum or plasma within 2 hours of collection. 
Transport temperature:
Refrigerated (preferred). Room temperature or frozen specimen also acceptable.
Specimen stability:
Room temperature: 1 day. Refrigerated: 2 days. Frozen: 6 months.
Rejection criteria:
Stability limits exceeded.

Reference interval:
Follicular phase 12.4-233 pg/mL
Ovulation phase 41.0-398 pg/mL
Luteal phase 22.3-341 pg/mL
Postmenopausal <50 pg/mL
MALES: 5-42.5 pg/mL

Interpretation guide:
First trimester 154 - 3243 pg/mL
Second trimester 1561 - 21280 pg/mL
Third trimester >8525 pg/mL
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Electrochemiluminescence Immunoassay
E2, UE2, ESTRA, Hormone
Clinical significance:
Estradiol levels are used in evaluating ovarian function. Estradiol levels are increased in cases of early (precocious) puberty in girls and gynecomastia in men. Its main use has been in the differential diagnosis of amenorrhea, for example, to determine whether the cause is menopause, pregnancy or a medical problem. In assisted reproductive technology (ART), serial measurements are used to monitor follicle development in the ovary in the days prior to in vitro fertilization. Estradiol is also sometimes used to monitor menopausal hormone replacement therapy.
Doctoral Director(s:)
Hoi-Ying Elsie Yu, PhD, DABCC, FADLM
Sheng-Ying (Margaret) Lo, PhD, DABCC    
Review Date: 12/14/2022

Performing Locations

Geisinger Medical Center

Performing laboratory: Automated Chemistry
Technical Lead: Megan Woodruff
Frequency: Daily, Monday-Sunday
Performed STAT? Yes

Geisinger Wyoming Valley Medical Center

Performing laboratory: ATL+
Technical Lead: Danielle Mostowski    
Frequency: Daily, all shifts    
Performed STAT? No
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