Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

HSP-70 ANTIBODY (ANTI-68 KD ANTIGEN)

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1755         Geisinger Epic ID: 23453

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
1 mL aliquot serum; minimum 0.5 mL.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge and aliquot. 
Transport temperature:
Room temperature.
Specimen stability:
Room Temperature: 7 days. Refrigerated: 14 days. Frozen: 21 days.
Rejection criteria:
Gross hemolysis, grossly lipemic

TEST DETAILS
CPT code(s):
84181
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
HSP-70 Antibody (Anti-68 KD Antigen).
Methodology:
Western Blot
Synonyms:
68KD, Meniere's Disease, 68 Kilodalton Antigen, Sensorineural Hearing Loss (SNHL), Heat Shock Protein 70, Quest test code 36734
Clinical significance:
Sensorineural hearing loss (SNHL), commonly referred to as nerve deafness, may be caused by genetic or acquired factors such as infections or can be immunologically mediated. A subgroup of idiopathic SNHL cases are treatable with immunosuppressive therapy. The laboratory work up to identify these cases should include serum antibody tests to 68kd inner ear antigen. Twenty-two percent of patients with bilateral rapidly progressive SNHL and 30% of the patients with Meniere's disease had antibodies that reacted with 68kd antigen present in the bovine inner ear extracts. Anti-68kd antibodies also occur in approximately 60% of patients with bilateral and 35% of patients with unilateral Meniere's Syndrome and 37% of patients with contralateral delayed endolymphatic hydrops.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Setup: Friday. Report available: 4 days.    
Performed stat? No
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