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LEGIONELLA PNEUMOPHILA ANTIBODY (IGM), IFA |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2578 Geisinger Epic ID: 17560 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
3.5 mL gold-top (serum separator) tube
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Specimen required: |
1 mL aliquot of serum; minimum 0.2 mL. If submitting this frozen a separate frozen aliquot for this test is needed. It may not be combined with any other test requiring a frozen aliquot. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Avoid repeated freeze/thaw cycles. | |
Transport temperature: |
Refrigerated. | |
Specimen stability: |
Room temperature: 7 days. Refrigerated: 14 days. Frozen: 30 days. | |
Rejection criteria: |
Stability limits exceeded. | |
TEST DETAILS |
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Reference interval: |
<1:256 titer | |
Additional information: |
IgM antibodies to Legionella pneumophila serogroup 1 and 6 additional L. pneumophila serogroups (2, 3, 4, 5, 6, 8) are measured using an IgM specific conjugate. We recommend that the IgM test always be performed in conjunction with the polyvalent antibody test. The IgM response to Legionella tends to develop concurrently with the IgG response and may remain elevated as long as the IgG response remains elevated. Cross reactions have been described with several species of bacteria and mycoplasma. | |
CPT code(s): |
86713 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Legionella pneumophila antibody IgM. | |
Methodology: |
Immunofluorescence Assay |
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Synonyms: |
Legionella pneumophila IgM, LGNGM Quest test code 30268
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Clinical significance: |
Legionella infection is associated with 2 clinically and epidemiologically distinct illnesses. Legionnaires disease and Pontiac fever. Legionnaires disease is characterized by fever, cough, myalgia, and pneumonia, whereas, Pontiac fever is a milder illness without pneumonia. Inhaling aerosols of water contaminated with Legionella species is believed to be the primary mode of Infection; the incubation period is generally 2-10 days. A 4-fold rise in IgG IFA Antibody titer to >1:128 between acute and convalescent sera may be used in the laboratory confirmation of Legionella infection. | |