Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

SM ANTIBODY

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB3060         Geisinger Epic ID: 26885

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
0.5 mL serum; minimum 0.2 mL.

SPECIMEN PROCESSING
Specimen processing instructions:
Allow to clot. Centrifuge and submit 0.5 mL serum. 
Transport temperature:
Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.
Specimen stability:
Room temperature: 8 hours. 2-8°C: 48 hours. Frozen: 6 months.
Rejection criteria:
Specimen stability exceeded; specimen grossly hemolyzed.

TEST DETAILS
Interpretation guide:
Normal range/negative < 20
Weak Positive 20-39
Moderate Positive 40-80
Strong Positive >80
CPT code(s):
86235
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
SM antibody.
Methodology:
Enzyme-Linked Immunosorbent Assay (ELISA)
Synonyms:
SMRE, SM, ENA (anti-extractable nuclear antigen)
Anti-Smith antibody
ANTI-ENA
Clinical significance:
Positive SM antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of systemic lupus erythematosus (SLE) and other related connective tissue diseases. SM antibodies are highly specific for SLE and are detected in appproximately 15% of patients with SLE.
Doctoral Director(s:)
Hoi-Ying Elsie Yu PhD, DABCC    
Review Date: 11/08/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Kathy Hurst
Frequency: Two days per week, 1st shift.
Performed stat? No
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