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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
HPV MRNA E6/E7, RECTAL |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1750 Geisinger Epic ID: 23506 | |
SPECIMEN COLLECTION |
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Specimen type: |
Dacron swab or anal-rectal brush collected in 3 mL PreservCyt ThinPrep® Preservative | |
Preferred collection container: |
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Specimen required: |
Dacron swab or anal-rectal brush collected in 3 mL PreservCyt ThinPrep® | |
Special notes: |
Collect an anal-rectal Dacron swab OR anal-rectal brush and swish vigorously in 3 mL PreservCyt® fluid in the ThinPrep® vial. Discard the swab or brush. Cap and tighten the ThinPrep® vial. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Specimen must be in PreservCyt ThinPrep® Preservative. | |
Transport temperature: |
Room temperature. | |
Specimen stability: |
Room Temperature: 30 days. Refrigerated: 28 days. Frozen: Unacceptable. | |
Rejection criteria: |
Improper transport medium. Stability limits exceeded. Liquid-based Pap smear sample not acceptable. Specimens received frozen. | |
TEST DETAILS |
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CPT code(s): |
87624 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Transcription-Mediated Amplification (TMA) |
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Synonyms: |
AHPV, Quest test code 91932
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Clinical significance: |
The presence of E6/E7 messenger RNA from 14 high risk HPV types indicates incorporation of HPV DNA into the host cells. Proteins expressed from E6-E7 polycistronic mRNA alter cellular p53 and retinoblastoma protein functions, leading to disruption of cell-cycle check points and cell genome instability. This information, together with the physician’s assessment of cytology history, other risk factors, and professional guidelines, may be used to guide patient management. | |