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Geisinger Medical Laboratories Test Catalog
CENTROMERE ANTIBODY |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1237 Geisinger Epic ID: 52873 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Specimen required: |
0.5 mL serum; minimum 0.2 mL | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Allow to clot. Centrifuge and submit 0.5 mL serum. | |
Transport temperature: |
Refrigerated (preferred). Room temperature (stable 8 hours) or frozen specimen also acceptable. | |
Specimen stability: |
Room temperature: 8 hours. Refrigerated (2-8°C): 72 hours. Frozen: 6 months | |
TEST DETAILS |
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Reference interval: |
Negative <7 U/mL | |
Interpretation guide: |
Negative: <7 U/mL Equivocal: 7-10 U/mL Positive: >10 U/mL |
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CPT code(s): |
86235 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Enzyme Immunoassay (EIA) |
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Clinical significance: |
The presence of centromere B antibodies in correlation with clinical findings can aid in the diagnosis of scleroderma (CREST syndrome). Centromere antibodies are found in 70-90% of patients with CREST syndrome, 10-20% of patients with Raynaud's phenomenon and primary biliary cirrhosis. | |
Doctoral Director(s:) |
Hoi-Ying Elsie Yu PhD, DABCC | |
| Review Date: | 12/13/2022 | |