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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
LRP4 AUTOANTIBODY TEST |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB4053 Geisinger Epic ID: 167868 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
2 mL serum; minimum 0.5 mL | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and aliquot. | |
Transport temperature: |
Room temperature. | |
Specimen stability: |
Room temperature: 72 hours. Refrigerated: 25 days. Frozen: 25 days. | |
TEST DETAILS |
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CPT code(s): |
86255 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Immunofluorescence Assay |
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Synonyms: |
Quest code 94744
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Clinical significance: |
Detects anti-LRP4 (low density lipoprotein receptor-related protein 4) in the sera of patients with Myasthenia Gravis (MG). The LRP4 protein activates MuSK kinase activity and promotes the clustering of AChR and their stabilization at the NMJ. Anti-LRP4 antibodies are found in approximately 9.2% (range 2% to 50%) of MG patients who are negative for both anti-AChR and anti-MuSK. | |