Geisinger Medical Laboratories Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB1357             Geisinger Epic ID: 53349

Specimen type:
Whole blood
Preferred collection container:
Alternate Collection Container:
4 mL green/green-top (sodium heparin) tube
Specimen required:
5 mL whole blood; minimum 3 mL.

Specimen processing instructions:
Specimen stability is crucial. Store and ship room temperature immediately. Do not freeze. 
Transport temperature:
Room temperature.
Specimen stability:
Room temperature: 8 days. Refrigerated: 8 days. Frozen: Unacceptable.
Rejection criteria:
Specimens received frozen.

Additional information:
This test was developed and its analytical performance characteristics have been determined by Quest Diagnostics. It has not been cleared or approved by FDA. This assay has been validated pursuant to the CLIA regulations and is used for clinical purposes.
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Polymerase Chain Reaction (PCR)
Quest test code 37742, TPMT Geno
Clinical significance:
Thiopurine S-methyltransferase (TPMT; S-adenosyl-L-methionine:thiopurine S-methyltransferase) catalyzes thiopurine S-methylation, an important metabolic pathway for antineoplastic and immunosuppressive drugs. In the US, 11% of the population show intermediate TPMT activity, and approximately 1 in 300 have TPMT deficiency. Given potentially fatal nature of hematopoietic toxicity when full doses of mercaptopurine or azathioprine are given to TPMT deficient patients, and the difficulty to measure TPMT activity accurately when patients have been given red cell transfusions, the molecular method to determine TPMT genotype permits prospective identification of patients at risk.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Wed, Fri; Report available: 6-7 days    
Performed STAT? No
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