Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

ANTIPHOSPHOLIPID ANTIBODY PANEL

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1353         Geisinger Epic ID: 53334

SPECIMEN COLLECTION
Specimen type:
Platelet-poor plasma (preferred) or serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
3.5 mL gold-top (serum separator) tube
Specimen required:
5 mL platelet-poor plasma; minimum 3 mL.

SPECIMEN PROCESSING
Specimen processing instructions:
Plasma (preferred): Centrifuge light blue-top tube 15 minutes at approximately 1500 x g within 60 minutes of collection. Using a plastic pipette, remove plasma, taking care to avoid the WBC/platelet buffy layer and place into a plastic vial. Centrifuge a second time and transfer platelet-poor plasma into a new plastic vial. Plasma must be free of platelets (< 10,000/mcL).
Serum: Centrifuge red-top tube 15 minutes at approximately 1500 x g within 24 hours of collection. Transfer serum into a plastic specimen vial. 
Transport temperature:
Room temperature.
Specimen stability:
Room temperature: 4 days. Refrigerated: 7 days. Frozen: 28 days.
Rejection criteria:
Gross hemolysis • Gross lipemia

TEST DETAILS
CPT code(s):
86146 (x3), 86147 (x3), 86148 (x3)
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM). Phosphatidylserine Antibodies (IgG, IgA, IgM). Cardiolipin Antibodies (IgA, IgG, IgM).
Methodology:
Immunoassay
Synonyms:
Quest test code 14890, Antiphosphol
Clinical significance:
The Antiphospholipid Antibody Syndrome (APS) is a clinical-pathologic correlation that includes a clinical event (e.g., thrombosis, pregnancy loss, thrombocytopenia) and persistent positive Antiphospholipid Antibodies (IgM or IgG ACA >40 MPL/GPL, IgM or IgG anti-B2GPI antibodies, or a Lupus Anticoagulant). The IgA isotype has been implicated in smaller studies, but has not yet been incorporated into the APS criteria. International consensus guidelines suggest waiting at least 12 weeks before retesting to confirm antibody persistence. Reference J Thromb Haemost 2006: 4; 295.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Tues-Sat; Report available: Next day    
Performed stat? No
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