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Geisinger Medical Laboratories Test Catalog
ANTIPHOSPHOLIPID ANTIBODY PANEL |
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Geisinger Epic Procedure Code: LAB1353
Geisinger Epic ID: 53334
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SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
3.5 mL gold-top (serum separator) tube
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Specimen required: |
5 mL serum; minimum 3 mL. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge red-top tube or SST 15 minutes at approximately 1500 x g within 24 hours of collection. Transfer serum into a plastic specimen vial. | |
Transport temperature: |
Refrigerated. | |
Specimen stability: |
Room temperature: 5 days. Refrigerated: 14 days. Frozen: 30 days. | |
Rejection criteria: |
Gross hemolysis • Gross lipemia | |
TEST DETAILS |
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CPT code(s): |
86146 (x3), 86147 (x3), 83516 (x2) | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Beta-2-Glycoprotein I Antibodies (IgG, IgA, IgM). Phosphatidylserine Antibodies (IgG, IgM). Cardiolipin Antibodies (IgA, IgG, IgM). | |
Methodology: |
Immunoassay |
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Synonyms: |
Quest test code 14890, Antiphosphol
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Clinical significance: |
The Antiphospholipid Antibody Syndrome (APS) is a clinical-pathologic correlation that includes a clinical event (e.g., thrombosis, pregnancy loss, thrombocytopenia) and persistent positive Antiphospholipid Antibodies (IgM or IgG ACA >40 MPL/GPL, IgM or IgG anti-B2GPI antibodies, or a Lupus Anticoagulant). The IgA isotype has been implicated in smaller studies, but has not yet been incorporated into the APS criteria. International consensus guidelines suggest waiting at least 12 weeks before retesting to confirm antibody persistence. Reference J Thromb Haemost 2006: 4; 295. | |