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Geisinger Medical Laboratories Test Catalog
TH/TO ANTIBODY |
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Geisinger Epic Procedure Code: LAB1322
Geisinger Epic ID: 53213
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SPECIMEN COLLECTION |
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Specimen type: |
Serum (preferred) or plasma | |
Preferred collection container: |
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Alternate Collection Container: |
3 mL lavender-top (K2 EDTA) tube
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Specimen required: |
1 mL serum (preferred) or plasma; minimum 0.5 mL | |
Special notes: |
Do not collect in gel tube. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and aliquot. | |
Transport temperature: |
Refrigerated (cold packs). | |
Specimen stability: |
Room temperature: 7 days. Refrigerated: 14 days. Frozen: 60 days. | |
TEST DETAILS |
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CPT code(s): |
83516 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Immunoprecipitation |
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Synonyms: |
Quest test code 91290 TH/TO Ab
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Clinical significance: |
The Th/To is a component of the 7-2/MRP RNP. Most of the 7-2/MRP RNP is found in the GC region of the nucleolus and <1% of this snoRNP appears located in mitochondria. The Th/To antibodies are present in 10-19% of patients with limited SSc, in 11% of patients with diffuse cutaneous SSc, and in 3% of patients with primary Raynaud’s disease. Anti-Th/To antibody has been shown to be highly specific for patients with SSc. The anti-Th/To antibody detection is an in-house bioassay performed at RDL for a qualitative determination of Th/To antibody in serum by immunoprecipitation. The Th/To antibody assay will be labeled as an “Analytic Specific Reagent (ASR) . | |