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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
THYROID CANCER (THYROGLOBULIN) MONITORING |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1317 Geisinger Epic ID: 53193 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
3 mL serum; minimum 1.5 mL. | |
Special notes: |
Dietary supplements containing biotin may interfere in assays and may skew results to be either falsely high or falsely low. For patients receiving the recommended daily doses of biotin, draw samples at least 8 hours following the last biotin supplementation. For patients on mega-doses of biotin supplements, draw samples at least 72 hours following the last biotin supplementation. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and aliquot. | |
Transport temperature: |
Refrigerated. | |
Specimen stability: |
Room temperature: 6 days. Refrigerated: 7 days. Frozen: 28 days. | |
Rejection criteria: |
Hemolysis • Lipemia • Plasma • Icteric | |
TEST DETAILS |
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CPT code(s): |
86800 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Thyroglobulin measurements are most useful in the postoperative monitoring of patients with papillary, follicular, and Hurthle cell carcinomas. However, approximately 20% of individuals develop autoantibodies to thyroglobulin. Since these antibodies interfere with immunoassay measurement of thyroglobulin, it is necessary to determine the presence or absence of antibodies before measuring thyroglobulin. This panel provides a sensitive method for determination of thyroglobulin autoantibodies, with subsequent measurement of thyroglobulin by either a sensitive immunoassay (Tg Ab negative samples) or LCMSMS (Tg Ab positive samples). The mass spectrometry assay has no interference from autoantibodies. | |
Methodology: |
Immunoenzymatic Assay |
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Synonyms: |
Quest test code 90814, Thyroid Canc, Thyroglobulin Antibody,Thyroglobulin Tumor Markers,Thyroglobulin (Tg)
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Clinical significance: |
Thyroglobulin measurements are most useful in the postoperative monitoring of patients with papillary, follicular, and Hurthle cell carcinomas. However, approximately 20% of individuals develop autoantibodies to thyroglobulin. Since these antibodies interfere with immunoassay measurement of thyroglobulin, it is necessary to determine the presence or absence of antibodies before measuring thyroglobulin. This panel provides a sensitive method for determination of thyroglobulin autoantibodies, with subsequent measurement of thyroglobulin by either a sensitive immunoassay (Tg Ab negative samples) or LCMSMS (Tg Ab positive samples). The mass spectrometry assay has no interference from autoantibodies. | |