Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

ANTITHROMBIN III ACTIVITY

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1770         Geisinger Epic ID: 17587

SPECIMEN COLLECTION
Specimen type:
Platelet-free plasma
Preferred collection container:
Alternate Collection Container:
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
Specimen required:
1 mL aliquot plasma.
Special notes:
Do not draw blood from a heparinized line. Avoid contaminating the sample with tissue thromboplastin or heparin. Venipuncture must be performed with no trauma. Hemolyzed samples are not acceptable. If blood is drawn from an indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected. If drawn with a butterfly setup, draw a discard first to remove air from tubing.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge the citrated blue-top tubes as soon as possible (within 60 minutes) at designated time and speed to obtain platelet-poor plasma (<10,000/µL). Using a plastic pipette, remove 1 mL of plasma and transfer to a plastic polypropylene aliquot tube and label with patient's name and a second patient identifier (e.g., date of birth, medical record number). Freeze upright and transport on dry ice. 
Transport temperature:
Frozen.
Specimen stability:
Frozen: -20°C for 30 days, -70°C for 6 months. Room temperature: 8 hours.
Rejection criteria:
Clotted specimen. Underfilled or overfilled tube. Stability limits exceeded. HCT > 55. HCT > 55 requires rejection, reorder in LIS, and recollection with proper adjustment of anticoagulant. Indications of thaw in transit are sample on slant in aliquot tube or in lid of tube. These samples will be run but will receive a comment of interpret results with caution as thawing suspected.

TEST DETAILS
Reference interval:
80-120%.
Additional information:
Anticoagulation Impact on Coagulation Tests
CPT code(s):
85300
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Antithrombin level.
Methodology:
Chromogenic
Synonyms:
AT3
Antithrombin 3
Antithrombin
Clinical significance:
Antithrombin 3 (AT3) is a blood protein produced in the liver that naturally prevents clot formation. AT3 works with heparin to stop clot production mainly by inhibiting thrombin (factor IIa) and factor Xa. Low AT3 levels increase risk of blood clots in patients and decrease response to heparin therapy. AT3 levels are low during or immediately after a blood clot, in patients with kidney or liver disease, and during heparin therapy.
Doctoral Director(s:)
Michelle Grant DO    
Review Date: 01/03/2021

Performing Locations

Geisinger Medical Center

Performing laboratory: Coagulation
Technical Lead: Margaret Knowles-Tuchman
Frequency: Daily, all shifts
Performed stat? Yes

Geisinger Wyoming Valley Medical Center

Performing laboratory: ATL+
Technical Lead: Julia Bell    
Frequency: Daily, all shifts    
Performed stat? Yes

Geisinger Community Medical Center

Performing laboratory: Hematology
Technical Lead: Renee Bordo, Robert Furcon  
Frequency: Daily    
Performed stat? Yes
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