Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

ANTITHROMBIN III

ORDERING INFORMATION:
Sunquest Test Code:
AT3      Geisinger Epic Procedure Code: 85300.01         Geisinger Epic ID: 17587

SPECIMEN COLLECTION
Specimen type:
Platelet-free plasma
Preferred collection container:
Alternate Collection Container:
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
Specimen required:
1 mL aliquot plasma.
Special notes:
Do not draw blood from a heparinized line. Avoid contaminating the sample with tissue thromboplastin or heparin. Venipuncture must be performed with no trauma. Hemolyzed samples are not acceptable. If blood is drawn from an indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected. If drawn with a butterfly setup, draw a discard first to remove air from tubing.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge the citrated blue-top tubes as soon as possible (within 60 minutes) at designated time and speed to obtain platelet-poor plasma (<10,000/µL). Using a plastic pipette, remove 1 mL of plasma and transfer to a plastic aliquot tube and label with patient's name and a second patient identifier (e.g., date of birth, medical record number). 
Transport temperature:
Frozen.
Specimen stability:
Frozen: -20°C for 30 days, -70°C for 6 months. Room temperature: 8 hours.
Rejection criteria:
Clotted specimen. Underfilled or overfilled tube. Stability limits exceeded. HCT > 55. HCT > 55 requires rejection, reorder in LIS, and recollection with proper adjustment of anticoagulant

TEST DETAILS
Reference interval:
80-120%.
CPT code(s):
85300
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Antithrombin level.
Methodology:
Chromogenic
Synonyms:
AT3
Antithrombin 3
Antithrombin
Clinical significance:
Antithrombin III is a very important inhibitor of the activated coagulation system. Deficiencies of antithrombin III can lead to a hypercoagulable state. A normal level of antithrombin III is necessary for therapeutic levels of unfractionated heparin to achieve their full effect. The level can be low in DIC, kidney disease, and heparin therapy.
Doctoral Director(s:)
Michelle Grant DO    
Review Date: 04/29/2019

Performing Locations

Geisinger Medical Center

Performing laboratory: Coagulation
Technical Lead: Margaret Knowles-Tuchman
Frequency: Daily, all shifts
Performed stat? Yes

Geisinger Wyoming Valley Medical Center

Performing laboratory: ATL+
Technical Lead: Amanda Mika    
Frequency: Daily, all shifts    
Performed stat? Yes

Geisinger Community Medical Center

Performing laboratory: Hematology
Technical Lead: Renee Bordo, Robert Furcon  
Frequency: Daily    
Performed stat? Yes
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*GMC - Geisinger Medical Center; GWV - Geisinger Wyoming Valley Medical Center; GSACH - Geisinger Shamokin Area Community Hospital; GBH - Geisinger Bloomsburg Hospital;
GCMC - Geisinger Community Medical Center (Scranton); GLH - Geisinger Lewistown Hospital; GHS - Geisinger Holy Spirit; GJSH - Geisinger Jersey Shore Hospital,
GSWB - Geisinger South Wilkes-Barre