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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
PROSTATIC ACID PHOSPHATASE (PAP) |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2930 Geisinger Epic ID: 17214 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
1 mL aliquot of serum; minimum 0.5 mL. Please submit a separate frozen aliquot for this test. It may not be combined with any other test requiring a frozen aliquot. | |
Special notes: |
Samples should be obtained before rectal examination, biopsy, prostatectomy, or prostatic massage, since manipulating the prostate gland may lead to elevated PAP levels persisting up to 24-48 hours. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Allow to clot. Centrifuge 10 minutes at 3000 rpm. | |
Transport temperature: |
Frozen. | |
Specimen stability: |
Room Temperature: 24 hours. Refrigerated: 24 hours. Frozen: 4 weeks. | |
Rejection criteria: |
Grossly hemolyzed samples. Stability limits exceeded. | |
TEST DETAILS |
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Reference interval: |
Male: <2.8 ng/mL Female: Not established |
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Additional information: |
PAP values from different assay methods cannot be used interchangeably. This assay was performed using the DPC Chemiluminescence method. | |
CPT code(s): |
84066 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Prostatic acid phosphatase. | |
Methodology: |
Immunoassay |
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Synonyms: |
ACID PHOS, PROSTATIC, PAP Quest test code 208
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Clinical significance: |
High concentrations of acid phosphatase are found in the prostate gland. Significant amounts are also found in platelets, bone, spleen, kidney and liver. Prostatic Acid Phosphatase (PAP) is a component of total acid phosphates and is a major constituent in seminal fluid and is also secreted in the urine. PAP is normally found in serum in very low levels. PAP measurement has found clinical application in the management of prostatic cancer patients. Serum PAP measurements have been useful in monitoring remission or relapse of a prostatic malignancy and in assessing the effectiveness of various treatment regimes. Thus, normalization in serum PAP levels has been observed following successful therapeutic intervention, while recurrent or residual disease has been associated with elevated levels of PAP. | |