Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) GENE MUTATION ANALYSIS

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1140         Geisinger Epic ID: 52485

SPECIMEN COLLECTION
Specimen type:
Whole blood
Preferred collection container:
Alternate Collection Container:
4 mL green/green-top (sodium heparin) tube
3 mL green/black top lithium heparin tube
Specimen required:
5 mL whole blood; minimum 3 mL.

SPECIMEN PROCESSING
Transport temperature:
Store and ship room temperature immediately. Do not freeze.
Specimen stability:
Room temperature: 8 days. Refrigerated: 8 days. Frozen: Unacceptable.
Rejection criteria:
Frozen specimen.

TEST DETAILS
CPT code(s):
81232
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Methodology:
Polymerase Chain Reaction (PCR)
Single Nucleotide Primer Extension
Synonyms:
Quest test code 15538, Dihydropyrim, IVS14+1G?A Mutation,DPD Gene Mutation Analysis
Clinical significance:
Partial or complete deficiency of DPD activity has been associated with an increased risk for severe adverse reactions when treated with pyrimidine-based chemotherapeutic agents, such as 5-fluorouracil (5-FU). The test can also be used to confirm the clinical diagnosis of dihydropyrimidine dehydrogenase (DPD) deficiency in affected patients and for the dectection of the IVS14+1G?A mutation in asymptomatic carriers.

Performing Locations

Quest Diagnostics or Viracor - see above

Technical Lead: Michael Weaver    
Frequency: Set up: Mon, Thurs; Report available: 7-11 days    
Performed stat? No
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