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DIHYDROPYRIMIDINE DEHYDROGENASE (DPD) GENE MUTATION ANALYSIS |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1140 Geisinger Epic ID: 52485 | |
SPECIMEN COLLECTION |
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Specimen type: |
Whole blood | |
Preferred collection container: |
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Alternate Collection Container: |
4 mL green/green-top (sodium heparin) tube
3 mL green/black top lithium heparin tube
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Specimen required: |
5 mL whole blood; minimum 3 mL. | |
| SPECIMEN PROCESSING |
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Transport temperature: |
Store and ship room temperature immediately. Do not freeze. | |
Specimen stability: |
Room temperature: 8 days. Refrigerated: 8 days. Frozen: Unacceptable. | |
Rejection criteria: |
Frozen specimen. | |
TEST DETAILS |
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CPT code(s): |
81232 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Polymerase Chain Reaction (PCR) Single Nucleotide Primer Extension |
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Synonyms: |
Quest test code 15538, Dihydropyrim, IVS14+1G?A Mutation,DPD Gene Mutation Analysis
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Clinical significance: |
Partial or complete deficiency of DPD activity has been associated with an increased risk for severe adverse reactions when treated with pyrimidine-based chemotherapeutic agents, such as 5-fluorouracil (5-FU). The test can also be used to confirm the clinical diagnosis of dihydropyrimidine dehydrogenase (DPD) deficiency in affected patients and for the dectection of the IVS14+1G?A mutation in asymptomatic carriers. | |