Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

PROTEIN C ACTIVITY

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB2932         Geisinger Epic ID: 17588

SPECIMEN COLLECTION
Specimen type:
Platelet-free plasma
Preferred collection container:
Alternate Collection Container:
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
Specimen required:
1 mL aliquot plasma
Special notes:
Perform venipuncture with minimal trauma to avoid hemolysis. If blood is drawn from an indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected to avoid contamination from heparin or tissue thromboplastin that is infused in line. If blood is drawn with a butterfly device, draw a discard tube first to remove air from tubing.
Patient preparation:
Patient must be off Coumadin 2 weeks prior to testing.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge the citrated blue-top tubes as soon as possible (within 60 minutes) at designated time and speed to obtain platelet-poor plasma (<10,000/µL). Using a plastic pipette, remove 1 mL of plasma and transfer to a plastic polypropylene aliquot tube and label with patient's name and a second patient identifier (e.g., date of birth, medical record number). Freeze upright and transport on dry ice. 
Transport temperature:
Frozen.
Specimen stability:
Room temperature: 8 hours. Frozen: -20°C for 30 days, -70°C for 6 months.
Rejection criteria:
Hemolyzed, hyperbilirubinemia, lipidemia, and clotted specimen. Indications of thaw in transit are sample on slant in aliquot tube or in lid of tube. These samples will be run but will receive a comment of interpret results with caution as thawing suspected.

TEST DETAILS
Reference interval:
75-135
Additional information:
Anticoagulation Impact on Coagulation Tests
CPT code(s):
85303
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Protein C activity.
Methodology:
Chromogenic
Synonyms:
Functional Protein C, PROTC
Clinical significance:
Deficiency of protein C is a risk factor for venous thrombosis. Low levels may be acquired or congenital. Acquired levels are from recent Coumadin therapy within 10 days, vitamin K deficiency, liver dysfunction, DIC, recent thrombosis or recent surgery.
Doctoral Director(s:)
Michelle Grant DO    
Review Date: 01/12/2021

Performing Locations

Geisinger Medical Center

Performing laboratory: Coagulation
Technical Lead: Margaret Knowles-Tuchman
Frequency: Daily, first shift
Performed stat? No
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