Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
PROTEIN C ACTIVITY |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2932 Geisinger Epic ID: 17588 | |
SPECIMEN COLLECTION |
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Specimen type: |
Platelet-free plasma | |
Preferred collection container: |
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Alternate Collection Container: |
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
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Specimen required: |
1 mL aliquot plasma | |
Special notes: |
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Patient preparation: |
Patient must be off Coumadin 2 weeks prior to testing. | |
SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge the citrated blue-top tubes immediately at designated time and speed to obtain platelet free plasma (<10,000/µL). Using a plastic pipette, carefully remove plasma from cells, avoiding platelet/buffy layer by leaving a thin layer of plasma on top the cells. The centrifuged plasma should be aliquoted (1 mL per aliquot) into clearly labeled polypropylene tubes. The number of tests ordered will determine the aliquots needed. Check the residual specimen for clot and if present discard sample and redraw specimen. Freeze upright and transport on dry ice.. | |
Transport temperature: |
Frozen. | |
Specimen stability: |
Room temperature: 8 hours. Frozen: -20°C for 30 days, -70°C for 6 months. | |
Rejection criteria: |
Clotted specimen. Stability exceeded. Overfilled or underfilled tubes. HCT > 55% and anticoagulant ratio not adjusted. Severely hemolyzed. Grossly icteric or lipemic can interfere with assay and may be rejected if interference is suspected.
Note: Specimen suspected of thawing in transport, indicated by slant in aliquot or specimen in lid of tube, will have testing performed, and the comment “interpret results with caution as thawing suspected” added to results. |
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TEST DETAILS |
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Reference interval: |
75-135 | |
Additional information: |
Anticoagulation Impact on Coagulation Tests | |
CPT code(s): |
85303 | |
Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Protein C activity. | |
Methodology: |
Chromogenic |
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Synonyms: |
Functional Protein C, PROTC
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Clinical significance: |
Deficiency of protein C is a risk factor for venous thrombosis. Low levels may be acquired or congenital. Acquired levels are from recent Coumadin therapy within 10 days, vitamin K deficiency, liver dysfunction, DIC, recent thrombosis or recent surgery. | |
Doctoral Director(s:) |
Michelle Grant DO | |
Review Date: | 01/12/2021 |