Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

CELIAC DISEASE COMPREHENSIVE PANEL

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1009         Geisinger Epic ID: 51961

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
5 mL serum; minimum 1 mL.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge and aliquot. 
Transport temperature:
Refrigerated (cold packs).
Specimen stability:
Room temperature: 72 hours. Refrigerated: 7 days. Frozen: 21 days.
Rejection criteria:
Gross hemolysis. Grossly lipemic.

TEST DETAILS
Additional information:
This panel is for patients who are >3 years old.
CPT code(s):
82784, 83516
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Tissue Transglutaminase (tTG) Antibody (IgA) IgA (Immunoglobulin A) If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected, then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255). If Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256). If Immunoglobulin A is less than the lower limit of the reference range, based on age, Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 83516).
Methodology:
Immunoassay
Immunoturbidometric Assay
Synonyms:
Quest test code 19955, Cel Comp Pnl
Clinical significance:
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy. Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance. The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Tues-Sat; Report available: Next day    
Performed stat? No
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