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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
CELIAC DISEASE COMPREHENSIVE PANEL |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1009 Geisinger Epic ID: 51961 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
5 mL serum; minimum 1 mL. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and aliquot. | |
Transport temperature: |
Refrigerated (cold packs). | |
Specimen stability: |
Room temperature: 72 hours. Refrigerated: 7 days. Frozen: 21 days. | |
Rejection criteria: |
Gross hemolysis. Grossly lipemic. | |
TEST DETAILS |
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Additional information: |
This panel is for patients who are >3 years old. | |
CPT code(s): |
82784, 83516 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Tissue Transglutaminase (tTG) Antibody (IgA) IgA (Immunoglobulin A) If Tissue Transglutaminase (tTG) Antibody (IgA) is Detected, then Endomysial Antibody Screen (IgA) will be performed at an additional charge (CPT code(s): 86255). If Endomysial Antibody Screen (IgA) is Positive, then Endomysial Antibody Titer will be performed at an additional charge (CPT code(s): 86256). If Immunoglobulin A is less than the lower limit of the reference range, based on age, Tissue Transglutaminase (tTG) Antibody (IgG) will be performed at an additional charge (CPT code(s): 83516). | |
Methodology: |
Immunoassay Immunoturbidometric Assay |
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Synonyms: |
Quest test code 19955, Cel Comp Pnl
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Clinical significance: |
Celiac disease is caused by an immune response to gluten in genetically sensitive individuals. The diagnosis is largely based on a biopsy of the small intestine, but serologic tests also help support a diagnosis and may assist identification of patients who may require biopsy. Tissue transglutaminase antibodies (tTG, IgA) is a marker with 95% sensitivity and specificity. Total IgA is measured because 2-3% of celiac disease patients are IgA deficient. Because tTG, IgA, and anti-Gliadin IgA tend to decrease in patients on a gluten-free diet, these markers are also used to assess dietary compliance. The endomysial antibody (EMA, IgA) assay has high specificity for celiac disease and is used to confirm positive anti-tTG results. | |