Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB3508         Geisinger Epic ID: 66456

Specimen type:
Whole blood
Preferred collection container:
Alternate Collection Container:
3 mL lavender-top (K2 EDTA) tube
Specimen required:
THREE 6 mL pink-top K2 EDTA tubes (minimum 4 mL each) whole blood OR SIX 3 mL lavender-top K2 EDTA tubes.
Special notes:
Collect THREE 6 mL pink-top K2 EDTA tubes OR SIX 3 mL lavender-top K2 EDTA tubes.

Specimen processing instructions:
Mix well immediately. Send/deliver all collection tubes to GMC Molecular Diagnostic Lab. Store at 2-8°C. Do not centrifuge. 
Transport temperature:
Refrigerated, 2-8°C. Send to GMC Molecular Diagnostic Lab.
Specimen stability:
Refrigerated, 2-8°C: 3 days. Specimen must be extracted within 3 days.
Rejection criteria:
Wrong collection tube. Improper storage or transport temperature. Stability limits exceeded. Shared or comingled specimens.

Reference interval:
Negative (no mutations detected).
Additional information:
For molecular testing, original tube is required.
CPT code(s):
81450, 81206 and/or 81207
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
BCR/ABL mutation detection by real-time PCR. Identification of JAK2, CALR, MPL, CSF3R, NRAS, PPM1D and TP53 mutations by Next-Generation Sequencing (NGS).
DNA Extraction
Real-time Polymerase Chain Reaction (PCR)
Next Generation Sequencing
RNA extraction
BCRABL, BCR-ABL, p210, p190, JAK2, JAK-2, Janus Tyrosine Kinase 2, CALR, Calreticulin, MPL, Thrombopoietin Receptor, CSF3R, Colony Stimulating Factor 3 Receptor, NRAS, N-RAS, Neuroblastoma RAS Viral Oncogene Homolog, PPM1D, Protein Phosphate, Mg2+/Mn2+ Dependent 1D, TP53, Tumor Protein p53, Thrombocytosis, MPD, Myeloproliferative Disorder
Clinical significance:
This test detects BCR-ABL mutations and BCR-ABL1-negative myeloproliferative disorders that are informative in the diagnosis and management of disease.
Doctoral Director(s:)
Yi Ding MD, PhD    
Review Date: 08/17/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Molecular Diagnostics
Technical Lead: Lisa Scicchitano
Frequency: NGS: Weekly on Tuesday. BCR-ABL: Weekly on Thursday
Performed stat? No
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