Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

THYROGLOBULIN AND THYROGLOBULIN AB FOR TUMOR MONITORING

ORDERING INFORMATION:
Sunquest Test Code:
TPTM      Geisinger Epic Procedure Code: TPTM         Geisinger Epic ID: 56526

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
Gold-top (serum separator) microcollection tube
Specimen required:
2 mL serum; minimum 1.5 mL
Special notes:
If collecting specimen in microcollection tubes, collect 3 FULL serum separator microcollection tubes.

SPECIMEN PROCESSING
Specimen processing instructions:
Allow to clot. Centrifuge and submit one (1) full 3.5 mL gold-top serum separator tube. Aliquot also acceptable (1.5 mL minimum). 
Transport temperature:
Refrigerated.
Specimen stability:
Thyroglobulin Tumor Monitoring: 5 days refrigerated and 28 days frozen.
Thyroglobulin AB Tumor Monitoring: 3 days refrigerated and 28 days frozen
Rejection criteria:
Stability limit exceeded.

TEST DETAILS
Reference interval:
Thyroglobulin Tumor Monitoring: <0.2 ng/mL
Thyroglobulin AB Tumor Monitoring: < 22 U/mL
Interpretation guide:
Thyroglobulin Tumor Monitoring:
Unstimulated thyroglobulin, athyroid: < 0.2 ng/mL
Stimulated thyroglobulin, athyroid: < 1 ng/mL

Thyroglobulin AB Tumor Monitoring:
The presence of anti-thyroglobulin antibodies may falsely decrease thyroglobulin result. Thyroglobulin testing by LC-MS/MS is recommended.
Additional information:
Thyroglobulin quantified by LC-MS/MS must be added on within 7 days from when results are released.
CPT code(s):
86800, 84432
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Thyroglobulin Tumor Monitoring and Thyroglobulin AB Tumor Monitoring
Methodology:
Chemiluminescence
Synonyms:
Clinical significance:
Thyroglobulin is used to monitor postoperative residual or recurrence of differentiated thyroid cancers. Up to 30 percent of this patient population, however, develops autoantibodies to thyroglobulin. These autoantibodies may interfere with in-house thyroglobulin immunometric assay and result in underestimation of thyroglobulin. When autoantibodies to thyroglobulin are present at or above 22 U/mL, thyroglobulin quantified by LC-MS/MS is recommended.
Doctoral Director(s:)
Stacy Kenyon, PhD, DABCC
Sheng-Ying (Margaret) Lo, PhD, DABCC    
Review Date: 12/10/2018

Performing Locations

Geisinger Medical Center

Performing laboratory: Automated Chemistry
Technical Lead: Mariana Moyer, Jared Shepherd
Frequency: Daily, all shifts
Performed stat? No

Geisinger Medical Center

Performing laboratory: Clinical Immunoassay (CIA)
Technical specialist: Karen Delp    
Frequency: Sunday, Tuesday-Friday, 1st shift    
Performed stat? No
   
   
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