Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

FACTOR 5 LEIDEN GENE MUTATION, PCR

ORDERING INFORMATION:
Sunquest Test Code:
PFVLM      Geisinger Epic Procedure Code: PFVLM         Geisinger Epic ID: 53657

SPECIMEN COLLECTION
Specimen type:
Whole blood
Preferred collection container:
Specimen required:
3 mL lavendar-top EDTA whole blood; minimum 0.5 mL. NO SHARED SPECIMENS WITH OTHER LABORATORY DEPARTMENTS. May be combined with other Molecular Diagnostic tests. For genetic testing, original tube required.
Special notes:
Mix well immediately.

SPECIMEN PROCESSING
Specimen processing instructions:
Do not centrifuge. 
Transport temperature:
Refrigerate (2-8°C).
Specimen stability:
Stable at room temperature for 24 hours; stable at 2-8°C (refrigerated) for 15 days.
Rejection criteria:
Stability limits exceeded. Shared or comingled specimens.

TEST DETAILS
Reference interval:
Negative.
Additional information:
For genetic tesing, original tube required.
CPT code(s):
81241
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Factor V Leiden mutation.
Methodology:
Real-time Polymerase Chain Reaction (PCR)
Synonyms:
Factor V mutation, factor V PCR, factor V DNA, factor V Leiden mutation, R506Q mutation
Clinical significance:
Factor V Leiden is a common cause of inherited thrombophilia. The R506Q mutation leads to resistance of degradation of the factor V protein by activated protein C (APC). Heterozygotes, or individuals who have one copy of the mutation, carry a 5- to 10-fold increased risk of venous thrombosis. Homozygotes, or individuals who have two copies of the mutation, carry at 50- to 100-fold increased risk.
Doctoral Director(s:)
Yi Ding MD, PhD    
Review Date: 09/05/2018

Performing Locations

Geisinger Medical Center

Performing laboratory: Molecular Diagnostics
Technical Lead: Lisa Scicchitano
Frequency: Monday, Wednesday, Friday, 1st shift
Performed stat? No
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