Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

PROTHROMBIN (FACTOR II) GENE MUTATION, PCR

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB2943         Geisinger Epic ID: 53656

SPECIMEN COLLECTION
Specimen type:
Whole Blood
Preferred collection container:
Specimen required:
3 mL lavendar-top EDTA whole blood; minimum 0.5 mL. NO SHARED SPECIMENS WITH OTHER LABORATORY DEPARTMENTS. May be combined with other Molecular Diagnostic tests. For genetic testing, original tube required.
Special notes:
Mix well immediately.

SPECIMEN PROCESSING
Specimen processing instructions:
Do not centrifuge. 
Transport temperature:
Refrigerate (2-8°C).
Specimen stability:
Stable at room temperature for 24 hours; stable at 2-8°C (refrigerated) for 15 days.
Rejection criteria:
Stability limits exceeded. Shared or comingled specimens.

TEST DETAILS
Reference interval:
Negative.
Additional information:
For genetic testing, original tube required.
CPT code(s):
81240
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Prothrombin gene mutation,
Methodology:
Real-time Polymerase Chain Reaction (PCR)
Synonyms:
Factor II, factor II DNA analysis, prothrombin gene mutation, factor II PCR, factor II mutation, PGM PCR, PGM mutation, PGM DNA, factor II DNA, G20210A mutation
PPGM
Clinical significance:
The G20210A mutation in the prothrombin (factor II) gene is the second most common inherited risk factor for venous thrombosis and is associated with elevated prothrombin concentrations. Heterozygous, or individuals who have one copy of the mutation, are at a 3- to 6-fold increased risk for venous thrombosis. Homozygotes, or individuals who have two copies of the mutation, are at an even higher risk.
Doctoral Director(s:)
Yi Ding MD, PhD    
Review Date: 08/17/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Molecular Diagnostics
Technical Lead: Lisa Scicchitano
Frequency: Monday, Wednesday, Friday, 1st shift
Performed stat? No
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