Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

HVA (HOMOVANILLIC ACID), 24 HR URINE W/CREATININE

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB2501         Geisinger Epic ID: 47275

SPECIMEN COLLECTION
Specimen type:
24-hour urine, collected with 25 mL 6N HCl (preferred)
Preferred collection container:
Alternate Collection Container:
24-hour urine container (no preservative)
Specimen required:
10 mL aliquot of 24-hour urine collection
Patient preparation:
Patient should avoid alcohol, coffee, tea, tobacco and strenuous exercise prior to collection. It is preferable for the patient to be off medications for three days prior to collection. However, common antihypertensives (diuretics, ACE inhibitors, calcium channel blockers, alpha and beta blockers) cause minimal or no interference.

SPECIMEN PROCESSING
Specimen processing instructions:
Lab personnel (to be determined per site) will test the pH of the urines and adjust to less than 3.0 using 6N HCl before Referred Testing ships the specimen. Urine without preservative is acceptable if pH is below 6 and the sample is shipped frozen. Record 24-hour urine volume and patient's age on test request form and urine vial. 
Transport temperature:
Room temperature.
Specimen stability:
Preserved: Room temperature:10 days. Refrigerated:14 days. Frozen:90 days.
Unpreserved: Frozen 30 days. Room temp and Refrigerated: Unacceptable
Rejection criteria:
Preserved urine received refrigerated with pH > 3; Unpreserved urine received frozen with pH > 6

TEST DETAILS
CPT code(s):
82570, 83150
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Methodology:
High Performance Liquid Chromatography (HPLC)
Synonyms:
Quest test code 39527, Homovanillic Acid
HVA24
Clinical significance:
Homovanillic acid (HVA, 4-hydroxy-3-methoxyphenylacetic acid) has been identified as the principal urinary metabolite of dopa and dopamine. HVA is excreted in free form in relatively large amounts, and is frequently measured to support a diagnosis of neuroblastoma and malignant pheochromocytoma. HVA has been used to monitor chronic lead exposure and response to medication, during the treatment of Parkinson's disease.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Tuesday, Thursday morning.    
Performed stat? No
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