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Geisinger Medical Laboratories Test Catalog
IGF-1, LC/MS |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2542 Geisinger Epic ID: 45921 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
0.5 mL serum; mnimum 0.3 mL | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and aliquot. If sample collected in glass collection tube, transfer to plastic container. | |
Transport temperature: |
Frozen. | |
Specimen stability: |
Room temperature: 48 hours. Refrigerated: 7 days. Frozen -20°C: 60 days. | |
Rejection criteria: |
Gross hemolysis. Gross lipemia. Received in glass tube. Grossly icteric. Plasma. | |
TEST DETAILS |
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CPT code(s): |
84305 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Liquid Chromatography Mass Spectrometry (LC/MS) |
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Synonyms: |
Quest test code 16293 IGF, IGF1, IGF-1 INSGF1
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Clinical significance: |
Insulin-like growth factor I (IGF-I, or somatomedin C), a protein involved in stimulating somatic growth, is regulated principally by growth hormone (GH) and nutritional intake. IGF-I is transported in serum by several proteins; this helps maintain relatively high IGF-I plasma levels and minimizes fluctuations in serum IGF-I concentrations. Measuring IGF-I is useful in several growth-related disorders. Dwarfism caused by deficiency of growth hormone (hypopituitarism) results in decreased serum levels of IGF-I, while acromegaly (growth hormone excess) results in elevated levels of IGF-I. IGF-I measurements are also helpful in assessing nutritional status; levels are reduced in undernutrition and restored with a proper diet. | |