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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
ACETYLCHOLINE RECEPTOR MODULATING ANTIBODY |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1511 Geisinger Epic ID: 45702 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
3.5 mL gold-top (serum separator) tube
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Specimen required: |
1 mL serum, minimum 0.5 ml | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and aliquot. | |
Transport temperature: |
Refrigerated. | |
Specimen stability: |
Room temperature: 14 days. Refrigerated: 14 days. Frozen: 30 days. | |
Rejection criteria: |
Microbially contaminated. Gross hemolysis. Grossly lipemic | |
TEST DETAILS |
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CPT code(s): |
83519 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Radio Binding Assay |
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Synonyms: |
AChR modulating Ab, Quest test code 26474 ACERMA
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Clinical significance: |
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR modulating antibodies cross-link AChR molecules on cell surface, promoting internalization, and decreasing AChR surface density. The AChR binding and modulating antibody assays have similar sensitivities, but performing them together increases sensitivity of antibody detection by approximately 5%. | |