Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

ACETYLCHOLINE RECEPTOR MODULATING AB

ORDERING INFORMATION:
Sunquest Test Code:
ACERMA      Geisinger Epic Procedure Code: ACERMA         Geisinger Epic ID: 45702

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
3.5 mL gold-top (serum separator) tube
Specimen required:
1 mL serum, minimum 0.5 ml

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge and aliquot. 
Transport temperature:
Refrigerated.
Specimen stability:
Room temperature: 14 days. Refrigerated: 14 days. Frozen: 30 days.
Rejection criteria:
Microbially contaminated. Gross hemolysis. Grossly lipemic

TEST DETAILS
CPT code(s):
83519
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Methodology:
Radio Binding Assay
Synonyms:
AChR modulating Ab, Quest test code 26474
Clinical significance:
Myasthenia Gravis (MG) is an autoimmune neuromuscular disorder characterized by muscle weakness, most commonly due to autoantibody-mediated loss of functional acetylcholine receptors (AChR) in the neuromuscular junction. AChR binding autoantibodies are diagnostic of MG, and are found in 85-90% of MG patients. AChR modulating antibodies cross-link AChR molecules on cell surface, promoting internalization, and decreasing AChR surface density. The AChR binding and modulating antibody assays have similar sensitivities, but performing them together increases sensitivity of antibody detection by approximately 5%.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Sunday, Tuesday, Thursday nights. Report available: 3-8 days.    
Performed stat? No
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