Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB3112         Geisinger Epic ID: 44052

Specimen type:
Preferred collection container:
Alternate Collection Container:
6 mL red-top (plain, non-serum separator) tube
Specimen required:
1.0 mL serum; minimum 0.5 mL

Specimen processing instructions:
Allow to clot. Centrifuge and submit 1 mL serum. 
Transport temperature:
Refrigerated (preferred). Room temperature (stable 8 hours) and frozen specimens also acceptable.
Specimen stability:
Room temperature: 8 hours. Refrigerated 2-8°C: 4 days (96 hours). Frozen: 6 months.
Rejection criteria:
Specimen stability exceeded; specimen grossly hemolyzed.

Reference interval:
ANA <1:80; DSDNA <1:10; RNPSM < 20.0; CARDG <15 GPL units; CARDA < 12 APL units; CARDM < 12 MPL units
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
ANA titer and pattern with reflex to a DSDNA, RNPSM, Cardiolipin IGG, Cardiolipin IGA, Cardiolipin IGM is ANA is positive
Indirect Immunofluorescent Antibody (IFA)
Enzyme-Linked Immunosorbent Assay (ELISA)
SLE reflex panel
Clinical significance:
The presence of ANA antibodies in correlation with clinical findings and other laboratory tests can aid in the diagnosis of certain rheumatic diseases including systemic lupus erythematosus (SLE), Sjogren's syndrome, mixed connective tissue disease, scleroderma, drug-induced lupus, and rheumatoid arthritis. High titers of antibodies to double-stranded DNA (dsDNA) are associated with systemic lupus erythematosus (SLE). The titer may decrease with succesful therapy and increase in acute recurrence of the disease.Positive RNP and SM antibodies can be used in conjunction with clinical findings and other laboratory tests to aid in the diagnosis of systemic lupus erythematosus (SLE) and other related connective tissue diseases. SM antibodies are highly specific for SLE and are detected in appproximately 15% of patients with SLE.The presence of cardiolipin antibodies when used in conjunction with clinical findings and other laboratory tests can aid in assessing the risk of thromboembolic disease in patients with systemic lupus erythematosus (SLE) or primary anti-phospholipid syndrome (APS).
Doctoral Director(s:)
Hoi-Ying Elsie Yu, PhD, DABCC
Stacy Kenyon, PhD, DABCC
Review Date: 12/03/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Immunology
Technical Lead: Kathy Hurst
Frequency: ANA IFA: Five days per week, 1st shift.
dsDNA: Five days per week, 1st shift.
RNPSM and Cardiolipin antibodies: Two days per week, 1st shift.
Performed stat? No
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