Geisinger Medical Laboratories Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  


Geisinger Epic Procedure Code: LAB2799             Geisinger Epic ID: 43810

Specimen type:
Whole blood
Preferred collection container:
Specimen required:
TWO 2 mL 3.2% sodium citrate blue-top tubes are required for each test.
Special notes:
Collect TWO sodium citrate tubes. Draw this tube prior to any other anticoagulant or additive tubes. Walk tube to laboratory (do not send via pneumatic tube or courier).

Perform venipuncture with no trauma. If blood is drawn from indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected to avoid contaminating sample with tissue thromboplastin or heparin. If using a butterfly needle setup for collection, draw a discard blue-top tube first to remove air from tubing. Specimen must be collected with a needle diameter no smaller than a 21 gauge.

Test is offered at a limited number of performing laboratories and may only be collected and performed at testing sites (see below). Send blood specimen to lab as soon as possible after collection.

If also drawing ASPIRIN, VERIFYNOW, specimen needs to be drawn in TWO separate tubes.

Specimen processing instructions:
Do NOT centrifuge. Uncentrifuged whole blood at room temperature required for analysis. Walk specimen to laboratory. 
Transport temperature:
Room temperature.
Specimen stability:
4 hours.
Rejection criteria:
Overfilled tube, underfilled tube, stability limit exceeded, tube system use, sent via courier, centrifugation of whole blood, HCT >55%, and other sizes or vendors' 3.2% sodium citrate tubes.

Reference interval:
182-335 PRU (P2Y12 reaction units)
Interpretation guide:
Effective drug use will manifest in a reading of PRU below the normal range. Results lower than the low reference range (182) are highly specific for a P2Y12 Inhibitor effect. If the sample was drawn 12 hours after administration of the medication, a normal PRU test will be observed based on validation studies. Resistance is seen in a small number of patients and will manifest as a normal value with appropriate drug usage confirmed.
CPT code(s):
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Plavix, InhibP
Platelet induced aggregation with turbidometric optical detection
Plavix test, Inhibition of plavix
Clinical significance:
Clopidogrel (Plavix) or similar drugs are anticoagulants used in patients with cardiovascular disease that block ADP induced platelet activation via the P2Y12 platelet receptor. The anticoagulants may cause prolonged surgical bleeding or bleeding associated with trauma.
Doctoral Director(s:)
Michelle Grant DO    
Review Date: 01/03/2023

Performing Locations

Geisinger Medical Center

Performing laboratory: Coagulation
Technical Lead: Margaret Knowles-Tuchman
Frequency: Daily, all shifts
Performed STAT? Yes

Geisinger Wyoming Valley Medical Center

Performing laboratory: Coagulation
Technical Lead: Jessica Kopeck    
Frequency: Daily, all shifts    
Performed STAT? Yes

Geisinger Community Medical Center

Performing laboratory: Hematology
Technical Lead: Robert Furcon  
Frequency: Daily, all shifts    
Performed STAT? Yes

Geisinger Lewistown Hospital

Performing laboratory: Coagulation
Technical Lead: Melissa Cramer  
Frequency: Daily, all shifts    
Performed STAT? Yes
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