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Geisinger Medical Laboratories Test Catalog
P2Y12 INHIBITOR REACTIVITY (CLOPIDOGREL), VERIFYNOW |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2799 Geisinger Epic ID: 43810 | |
SPECIMEN COLLECTION |
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Specimen type: |
Whole blood | |
Preferred collection container: |
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Alternate Collection Container: |
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
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Specimen required: |
TWO 2 mL 3.2% sodium citrate blue-top tubes are required for each test. | |
Special notes: |
Collect TWO sodium citrate tubes. Draw this tube prior to any other anticoagulant or additive tubes. Walk tube to laboratory (do not send via pneumatic tube or courier). Perform venipuncture with no trauma. If blood is drawn from indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected to avoid contaminating sample with tissue thromboplastin or heparin. If using a butterfly needle setup for collection, draw a discard blue-top tube first to remove air from tubing. Specimen must be collected with a needle diameter no smaller than a 21 gauge. Test is offered at a limited number of performing laboratories and may only be collected and performed at testing sites (see below). Send blood specimen to lab as soon as possible after collection. If also drawing ASPIRIN, VERIFYNOW, specimen needs to be drawn in TWO separate tubes. |
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| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Do NOT centrifuge. Uncentrifuged whole blood at room temperature required for analysis. Walk specimen to laboratory. | |
Transport temperature: |
Room temperature. | |
Specimen stability: |
4 hours. | |
Rejection criteria: |
Overfilled tube, underfilled tube, stability limit exceeded, tube system use, sent via courier, centrifugation of whole blood, HCT >55%. | |
TEST DETAILS |
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Reference interval: |
182-335 PRU (P2Y12 reaction units) | |
Interpretation guide: |
Effective drug use will manifest in a reading of PRU below the normal range. Results lower than the low reference range (182) are highly specific for a P2Y12 Inhibitor effect. If the sample was drawn 12 hours after administration of the medication, a normal PRU test will be observed based on validation studies. Resistance is seen in a small number of patients and will manifest as a normal value with appropriate drug usage confirmed. | |
CPT code(s): |
85576 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Plavix, InhibP | |
Methodology: |
Platelet induced aggregation with turbidometric optical detection |
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Synonyms: |
Plavix test, Inhibition of plavix PFPLAV, VERIFY P2Y12
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Clinical significance: |
Clopidogrel (Plavix) or similar drugs are anticoagulants used in patients with cardiovascular disease that block ADP induced platelet activation via the P2Y12 platelet receptor. The anticoagulants may cause prolonged surgical bleeding or bleeding associated with trauma. | |
Doctoral Director(s:) |
Mary Dhesi MD | |
| Review Date: | 01/03/2023 | |
Performing Locations
Geisinger Wyoming Valley Medical Center