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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
FISH, ALL/MPD, DEL9P21/+9 |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB1552 Geisinger Epic ID: 43768 | |
SPECIMEN COLLECTION |
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Specimen type: |
Bone marrow (preferred) or whole blood | |
Preferred collection container: |
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Alternate Collection Container: |
Bone marrow culture transport media
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Specimen required: |
3 mL bone marrow in sodium heparin tube (preferred) or culture media, or 5 mL whole blood in sodium heparin tube | |
Special notes: |
Clinical history and reason for referral are required with test order | |
| SPECIMEN PROCESSING |
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Transport temperature: |
Room temperature. | |
Specimen stability: |
Specimen viability decreases during transit. Send specimen to testing laboratory for viability determination. Do not reject. | |
Rejection criteria: |
Frozen specimens unacceptabe. | |
TEST DETAILS |
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Additional information: |
Test is not orderable in EPIC but results will file to EPIC | |
CPT code(s): |
88275, 88271 x2 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Methodology: |
Fluorescence In Situ Hybridization (FISH) |
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Synonyms: |
Quest test code 16120X ALLMPD
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Clinical significance: |
Deletions of 9p21 region are found mainly in acute lymphoblastic leukemia (ALL), occurring in approximately 10% of both pediatric and adult cases. The deletion is an adverse risk factor for B-lineage ALL, but not for T-lineage. Trisomy 9 and additional copies of 9p, due to unbalanced chromosome rearrangements, are recurrent abnormalities in chronic myeloproliferative disorders (MPD), including polycythemia vera, essential thrombocythemia, and myelofibrosis. | |