Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

FISH, HER-2/NEU, PARAFFIN BLOCK
ORDERING INFORMATION:	Geisinger Epic Procedure Code: LAB2293 Geisinger Epic ID: 43766
SPECIMEN COLLECTION
Specimen type:	Tissue
Specimen required:	1 formalin-fixed, paraffin-embedded tumor tissue block, or 6 unstained, positively charged (+) slides, prepared from formalin-fixed, paraffin-embedded tissue. Pathology report must accompany paraffin block or slides.
Special notes:	Test is performed on formalin-fixed, paraffin-embedded tissue from invasive or metastatic breast cancer.
SPECIMEN PROCESSING
Transport temperature:	Room temperature.
Specimen stability:	Block: Room temperature: Indefinitely. Refrigerated: Indefinitely. Frozen: Unacceptable. Slides: Room temperature: 42 days
Rejection criteria:	Fixatives other than formalin. o not freeze.
TEST DETAILS
CPT code(s):	88377
	Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Methodology:	Fluorescence In Situ Hybridization (FISH)
Synonyms:	Quest code 14620, PathVysion®, c-erbB2 H2NBLK
Clinical significance:	HER-2 oncogene amplification in stage 2 lymph node positive breast cancer which aids in treatment selection and prognostication