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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
DOUBLE STRANDED DNA ANTIBODY, INDIRECT IMMUNOFLUORESCENCE ASSAY |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2195 Geisinger Epic ID: 41802 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
6 mL red-top (plain, non-serum separator) tube
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Specimen required: |
0.5 mL serum; minimum 0.2 mL | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Allow to clot. Centrifuge and submit 0.5 mL serum. | |
Transport temperature: |
Refrigerated (preferred). Room temperature (stable 8 hours) or frozen specimen also acceptable. | |
Specimen stability: |
Room temperature: 8 hours. 2-8°C: 72 hours. Frozen: 6 months. | |
Rejection criteria: |
Specimen stability exceeded; specimen grossly hemolyzed. | |
TEST DETAILS |
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Reference interval: |
<1:10 | |
CPT code(s): |
86225 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Antibody detection and titer if positive. | |
Methodology: |
Indirect Immunofluorescent Antibody (IFA) |
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Synonyms: |
Anti-DNA Antibody, Anti-Native DNA, Anti-Double Stranded DNA, Crithidia Assay Double stranded anti-DNA antibody DSDNA
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Clinical significance: |
High titers of antibodies to double-stranded DNA (dsDNA) are associated with systemic lupus erythematosus (SLE). The titer may decrease with succesful therapy and increase in acute recurrence of the disease. | |
Doctoral Director(s:) |
Hoi-Ying Elsie Yu PhD, DABCC | |
| Review Date: | 12/13/2022 | |