Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

ALK PHOS ISOENZYMES

ORDERING INFORMATION:
Sunquest Test Code:
ALKPI      Geisinger Epic Procedure Code: 84075.06         Geisinger Epic ID: 17782

SPECIMEN COLLECTION
Specimen type:
Serum
Preferred collection container:
Alternate Collection Container:
3.5 mL gold-top (serum separator) tube
Specimen required:
2 mL aliquot of serum; minimum 1 mL.
Special notes:
Centrifuge within 30 minutes of collection.
Patient preparation:
Overnight fasting is preferred.

SPECIMEN PROCESSING
Specimen processing instructions:
Allow to clot. Centrifuge within 30 minutes of collection and transfer serum to a clean, plastic transfer vial and transport room temperature. 
Transport temperature:
Room temperature (preferred). Refrigerated or frozen specimen also acceptable.
Specimen stability:
Room Temperature: 7 days. Refrigerated: 21 days. Frozen: 21 days.
Rejection criteria:
Stability limits exceeded.

TEST DETAILS
Reference interval:
Alkaline Phosphatase
Age Males (U/L) Females (U/L)
< 1 month 75-316 48-406
1-11 mos 82-383 124-341
1-3 yrs 104-345 108-317
4-6 yrs 93-309 96-297
7-9 yrs 47-324 184-415
10-12 yrs 91-476 104-471
13-15 yrs 92-468 41-244
16-19 yrs 48-230 47-176
> or = 20 yrs 40-115 40-115
20-49 yrs 33-115 33-115
> or = 50 yrs 33-130 33-130
     

ALP
Age Intestinal (%) Bone (%) Liver (%)
Adult 1-24 28-66 25-69
< 4 yrs Not established Not established Not established
4-9 yrs 2-4 67-87 9-24
10-13 yrs 2-12 68-89 8-28
14-17 yrs 1-13 46-90 8-63
RR: Macrohepatic Isoenzymes 0% If result > 0%, the following comment will be printed on reports: It is recognized that the presence of the Macrohepatic ALP isoenzyme reflects release of membrane-attached enzyme from hepatocytes with cholestasis, and thus usually reflects the presence of cholestasis. However, is has also been isolated in patients with other liver diseases such as viral hepatitis, alcoholic cirrhosis, and carcinoma of the liver.
RR: Placental Isoenzymes 0%
CPT code(s):
84075, 84080
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Alkaline Phosphatase, Intestinal Isoenzymes, Bone Isoenzymes, Liver Isoenzymes, Placental Isoenzymes, Macrohepatic Isoenzymes
Methodology:
Agarose Electrophoresis (AE)
Synonyms:
Alkaline phosphatase isoenzymes
Quest test code 231
Clinical significance:
When the Total Alkaline Phosphatase activity is increased, the Isoenzymes are useful in determining the source of the increased activity.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Set up: Sun-Fri evenings; Report available: Next day.    
Performed stat? No
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