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LIVER KIDNEY MICROSOMAL (LKM-1) ANTIBODY (IGG) |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2617 Geisinger Epic ID: 7363 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Alternate Collection Container: |
3.5 mL gold-top (serum separator) tube
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Specimen required: |
1 mL aliquot of serum; minimum 0.3 mL. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and transfer serum specimens to sterile, plastic, screw-capped vial(s). | |
Transport temperature: |
Refrigerated (preferred) or frozen. | |
Specimen stability: |
Room Temperature: 4 days. Refrigerated: 2 weeks. Frozen: 1 month (-20°C). | |
Rejection criteria: |
Stability limits exceeded. | |
TEST DETAILS |
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Reference interval: |
LKM-1 IgG Ab = or < 20.0 Units: Negative 20.1-24.9 Units: Equivocal > or = 25.0 Units: Positive Detection limits 1.0-120.0 Units |
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Additional information: |
Liver-kidney microsomal (LKM) antibodies are highly sensitive and specific for autoimmune hepatitis (AIH) type 2. The target antigen is cytochrome P450 2D6, which is localized to endoplasmic reticulum. This specific antigen is now available in an FDA-cleared EIA format that is more specific than IFA. This reactivity is not associated with AIH type 1 (lupoid AIH) or with LKM-3 positivity, which has been found in hepatitis D infection. Approximately 8% of patients with chronic hepatitis C infection are also LKM-1 reactive. | |
CPT code(s): |
86376 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Liver-kidney microsomal (LKM) antibodies | |
Methodology: |
Enzyme Immunoassay (EIA) |
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Synonyms: |
LIVER/KIDNEY MICROSOMAL AB, LKM Quest test code 71902
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