Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

KRAS MUTATION ANALYSIS

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1144         Geisinger Epic ID: 35424

SPECIMEN COLLECTION
Specimen type:
Formalin-fixed, paraffin-embedded tissue (FFPE)
Specimen required:
Two (2) 15 micron sections in 50 mL tube (preferred), four (4) 10 micron FFPE unstained slides with H&E or paraffin block.
Special notes:
For requests from non-Geisinger sites, please send: Five (5) 15 micron FFPE sections (scrolls)-preferred specimen, H&E slide, source of specimen, and tumor assessment (<10% or >10%). Alternatively, send FFPE block. Isolated/extracted nucleic acids are acceptable only from CLIA-certified laboratories or a laboratory meeting equivalent requirements as determined by CAP and/or CMS.

SPECIMEN PROCESSING
Transport temperature:
Room temperature (18-25ÂșC).
Specimen stability:
Indefinitely.
Rejection criteria:
Blocks containing no tumor (evaluated by pathologist) will be rejected. FFPE tissues that have been decalcified. Insufficient DNA.

TEST DETAILS
Reference interval:
Negative for mutation(s) tested.
CPT code(s):
81275, 81276
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
Identification of KRAS mutations in codons 12, 13, 59, 61, 117, and 146.
Methodology:
Real-time Polymerase Chain Reaction (PCR)
Synonyms:
K-ras, KRAS gene, K-RAS protein
Clinical significance:
Testing for KRAS mutations is used to predict response to anti-EGFR and MAPK pathway therapies in a variety of malignancies (e.g. colorectal and lung cancer).
Doctoral Director(s:)
Yi Ding MD, PhD    
Review Date: 08/17/2020

Performing Locations

Geisinger Medical Center

Performing laboratory: Molecular Diagnostics
Technical Lead: Lisa Scicchitano
Frequency: Daily, Monday-Friday
Performed stat? No
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