Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Test Name: Sunquest Test Code Epic Procedure Code Or ID CPT Code:  

BRAF MUTATION, REFERRED

ORDERING INFORMATION:
Sunquest Test Code:
BRAF      Geisinger Epic Procedure Code: BRAF         Geisinger Epic ID: 34914

SPECIMEN COLLECTION
Specimen type:
Whole blood
Preferred collection container:
Specimen required:
4 mL EDTA whole blood
Special notes:
For blocks order EPIC code BRAFMU.

SPECIMEN PROCESSING
Transport temperature:
Room temperature.
Specimen stability:
Whole blood: Room temperature: 72 hours. Refrigerated: 72 hours. Frozen: Unacceptable.
Rejection criteria:
Frozen specimen unacceptable.

TEST DETAILS
Reference interval:
Not detected.
Additional information:
This testing is only for whole blood. For blocks please order our test code BRAFMU.
CPT code(s):
81210
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
BRAF mutation analysis.
Methodology:
Direct sequencing
Synonyms:
Quest test code 16767
Clinical significance:
BRAF encodes a serine/threonin protein kinase downstream of the epidermal growth factor receptor (EGFR) and the RAS family of small G-proteins (KRAS, HRAS, and NRAS) in the MAPK pathway. BRAF is mutated in approximately 8-10% of human tumors (Davis et al. 2002), most frequently in melanoma (50-70%) and in papillary thyroid cancer (36-69%). BRAF muations are also found with lower frequency in colorectal cancer (5-12%), Non-small cell lung cancer (NSCLC), acute myeloid leukemia (AML), glioma, sarcomas, breast cancer, heptoma, and ovarian cancer.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Monday, Thursday morning    
Performed stat? No
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