Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

CHRONIC LYMPHOCYTIC LEUKEMIA, IGVH, CELL-BASED

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB2025         Geisinger Epic ID: 33420

SPECIMEN COLLECTION
Specimen type:
Whole blood (preferred ) or bone marrow (also acceptable).
Preferred collection container:
Alternate Collection Container:
4 mL green/green-top (sodium heparin) tube
Specimen required:
6 mL whole blood, minimum min 4mL, in EDTA or sodium heparin tube OR 3 mL bone marrow, minimum 1mL in EDTA tube.

SPECIMEN PROCESSING
Specimen processing instructions:
Samples must arrive at Quest Diagnostics within 24 hours of collection. 
Transport temperature:
Refrigerated.
Specimen stability:
Room Temperature: 72 hours. Refrigerated: 72 hours. Frozen: Unacceptable.
Rejection criteria:
Frozen specimen.

TEST DETAILS
Reference interval:
Report.
CPT code(s):
81263
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
CLL, IgVH Mutation Status
Methodology:
Real-time Polymerase Chain Reaction (PCR)
Synonyms:
Chronic Lymphocytic Leukemia IgVH
Quest test code 15480
CLIGVH
Clinical significance:
The IgVH gene mutation status of a B-cell chronic lymphocytic leukemia (CLL) clone present in this sample was determined by PCR-based Sanger DNA sequencing, following reverse transcription of extracted nucleic acid. In CLL cases with unmutated IgVH gene, patients usually have more aggressive disease and shorter survival compared to those with mutated IgVH. Specimens in which the CLL clone comprises less than 25% of total B cells may not yield an interpretable result.

Performing Locations

Quest Diagnostics

Technical Lead: Michael Weaver    
Frequency: Monday-Thursday morning    
Performed stat? No
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