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Geisinger Medical Laboratories Test Catalog
CHRONIC LYMPHOCYTIC LEUKEMIA, IGVH, CELL-BASED |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2025 Geisinger Epic ID: 33420 | |
SPECIMEN COLLECTION |
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Specimen type: |
Whole blood (preferred ) or bone marrow (also acceptable). | |
Preferred collection container: |
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Alternate Collection Container: |
4 mL green/green-top (sodium heparin) tube
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Specimen required: |
6 mL whole blood, minimum min 4mL, in EDTA or sodium heparin tube OR 3 mL bone marrow, minimum 1mL in EDTA tube. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Samples must arrive at Quest Diagnostics within 24 hours of collection. | |
Transport temperature: |
Refrigerated. | |
Specimen stability: |
Room Temperature: 72 hours. Refrigerated: 72 hours. Frozen: Unacceptable. | |
Rejection criteria: |
Frozen specimen. | |
TEST DETAILS |
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Reference interval: |
Report. | |
CPT code(s): |
81263 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
CLL, IgVH Mutation Status | |
Methodology: |
Real-time Polymerase Chain Reaction (PCR) |
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Synonyms: |
Chronic Lymphocytic Leukemia IgVH Quest test code 15480 CLIGVH
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Clinical significance: |
The IgVH gene mutation status of a B-cell chronic lymphocytic leukemia (CLL) clone present in this sample was determined by PCR-based Sanger DNA sequencing, following reverse transcription of extracted nucleic acid. In CLL cases with unmutated IgVH gene, patients usually have more aggressive disease and shorter survival compared to those with mutated IgVH. Specimens in which the CLL clone comprises less than 25% of total B cells may not yield an interpretable result. | |