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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
HLA B27 ANTIGEN |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB2476 Geisinger Epic ID: 33443 | |
SPECIMEN COLLECTION |
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Specimen type: |
Whole blood | |
Preferred collection container: |
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Alternate Collection Container: |
4 mL green/green-top (sodium heparin) tube
3 mL lavender-top (K2 EDTA) tube
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Specimen required: |
Properly drawn ACD yellow or sodium heparin tube whole blood. | |
Special notes: |
Collect and send promptly. Transport just before or during weekends or holidays could result in preassay delay and should be avoided. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Do not centrifuge, refrigerate or freeze. | |
Transport temperature: |
Room temperature in styrofoam container, do not expose to extremes of temperature. | |
Specimen stability: |
Stable 72 hours at room temperature. | |
Rejection criteria: |
Stability exceeded, hemolyzed, clotted or frozen specimens. | |
TEST DETAILS |
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Reference interval: |
Not detected. | |
Additional information: |
Frequency of occurrence: 6-8% in Caucasians; 3-4% in African-Americans; 1% in Asians. | |
CPT code(s): |
86812 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Detection of HLA-B27 in whole blood. | |
Methodology: |
Flow Cytometry |
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Synonyms: |
HLB27 HLAB27 B27H
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Clinical significance: |
There is a strong association between the presence of HLA-B27 antigen and an increased incidence of ankylosing spondylitis as well as several other disorders, such as Reiter's syndrome, psoriatic arthritis, and arthroplasties associated with inflammatory bowel diseases. These disorders are collectively known as the seronegative spondyloarthropathies. An HLA-B27-positive patient is more likely to exhibit spondyloarthropathies than an HLA-B27-negative person. | |
Doctoral Director(s:) |
Kai Zhang M.D. | |
| Review Date: | 12/14/2022 | |