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Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog
TSI (THYROID STIMULATING IMMUNOGLOBULIN) |
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ORDERING INFORMATION: |
Geisinger Epic Procedure Code: LAB3161 Geisinger Epic ID: 17556 | |
SPECIMEN COLLECTION |
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Specimen type: |
Serum | |
Preferred collection container: |
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Specimen required: |
1 mL aliquot of serum; minimum 0.2 mL. | |
| SPECIMEN PROCESSING |
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Specimen processing instructions: |
Centrifuge and transfer serum specimens to clean, plastic, screw-capped vial(s). Transport on refrigerant coolant. | |
Transport temperature: |
Refrigerated. | |
Specimen stability: |
Refrigerated: 21 days (preferred). Frozen: 60 days. | |
Rejection criteria: |
Room temperature specimens will be rejected. Grossly hemolyzed, iteric and lipemic specimens will be rejected. | |
TEST DETAILS |
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Reference interval: |
< 140% of baseline. | |
Additional information: |
Please note: A serum TSH level >25 uIU/mL can interfere with the TSI bioassay, and potentially give higher TSI results | |
CPT code(s): |
84445 | |
| Note: The billing party has sole responsibility for CPT coding. Any questions regarding coding should be directed to the payer being billed. The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only. | ||
Test includes: |
Thyroid Stimulating Immunoglobulin | |
Methodology: |
Immunoassay |
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Synonyms: |
Thyroid Stimulating Immun, THSI Quest test code 30551
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Clinical significance: |
Graves' disease is a classic form of hyperthyroid disease, affecting approximately 0.4% of the population in the United States. It is caused by IgG immunoglobulins, collectively known as thyroid stimulating immunoglobulins (TSI). Patients who are candidates for antithyroid drug therapy may not respond to this treatment when TSI levels are markedly elevated. The determination of TSI can also assist in predicting hyperthyroidism in neonates, due to placental transmission of the immunoglobulins from a mother with hyperthyroidism. | |