Geisinger Medical Laboratories/Geisinger Proven Diagnostics Test Catalog

Order Display Name: Geisinger Epic Procedure Code Or ID CPT Code:  

ACTIVATED PROTEIN C RESISTANCE

ORDERING INFORMATION:
Geisinger Epic Procedure Code: LAB1515         Geisinger Epic ID: 19435

SPECIMEN COLLECTION
Specimen type:
Platelet-free plasma
Preferred collection container:
Alternate Collection Container:
Other size blue-top (3.2% sodium citrate) tubes (e.g., 1.8 mL, 4.5 mL)
Specimen required:
1 mL aliquot of plasma.
Special notes:
Do not draw blood from a heparinized line. Avoid contaminating the sample with tissue thromboplastin or heparin. Venipuncture must be performed with no trauma. If blood is drawn from an indwelling catheter, flush with 5 mL of saline and discard the first 5 mL of blood collected.
Patient preparation:
Patient should be at rest for at least 10 minutes before collecting specimen.

SPECIMEN PROCESSING
Specimen processing instructions:
Centrifuge the citrated blue-top tubes as soon as possible (within 60 minutes) at designated time and speed to obtain platelet-poor plasma (<10,000/µL). Using a plastic pipette, remove 1 mL of plasma and transfer to a plastic polypropylene aliquot tube and label with patient's name and a second patient identifier (e.g., date of birth, medical record number). Freeze upright and transport on dry ice. 
Transport temperature:
Frozen.
Specimen stability:
Froom temperature: 4 hours. Frozen: -20°C for 30 days, -70°C for 6 months.
Rejection criteria:
Clotted specimen. Stability limits exceeded. Overfilled or underfilled tubes. Indications of thaw in transit are sample on slant in aliquot tube or in lid of tube. These samples will be run but will receive a comment of interpret results with caution as thawing suspected.

TEST DETAILS
Reference interval:
Greater than 2.1.
CPT code(s):
85307
Note: The billing party has sole responsibility for CPT coding.  Any questions regarding coding should be directed to the payer being billed.  The CPT codes provided by GML are based on AMA guidelines and are for informational purposes only.
Test includes:
APC ratio.
Methodology:
Mechanical Clot-Based
Synonyms:
APC, APC Resistance, Resistance to Activated Protein C. APROTC
Clinical significance:
The activated protein C resistance test is a clot-based screening test used to detect the possible existence of the Factor V Leiden mutation in patients. Patients with Factor V Leiden mutation are at risk for venous thrombosis.
Doctoral Director(s:)
Michelle Grant DO    
Review Date: 04/29/2019

Performing Locations

Geisinger Medical Center

Performing laboratory: Coagulation
Technical Lead: Margaret Knowles-Tuchman
Frequency: Daily, first shift
Performed stat? No
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